目的 探讨丹青胶囊联合他扎罗汀倍他米松治疗银屑病的临床疗效。方法 选取2019年6月—2021年6月在天津市职业病防治院门诊皮肤科就诊治疗的114例银屑病患者，根据随机数字法分为对照组和治疗组，每组各57例。对照组患者给予他扎罗汀倍他米松乳膏，洗净患处，待皮肤干爽后，将适量本品均匀涂抹于患处，1次/d。治疗组患者在对照组治疗基础上口服丹青胶囊，4粒/次，3次/d。两组患者均连续治疗7 d。观察两组患者的临床疗效和临床症状好转时间，比较两组治疗前与治疗1、4、8周的皮损面积和严重程度指数（PASI）评分和血清炎性因子水平。结果 治疗后，治疗组总有效率是98.25%，显著高于对照组的82.46%（P<0.05）。治疗后，治疗组患者皮损暗红、皮损肥厚、皮肤瘙痒、皮肤疼痛等症状好转时间均显著短于对照组（P<0.05）。治疗后，两组PASI评分均较治疗前显著降低（P<0.05）；治疗1、4、8周治疗组PASI评分显著低于对照组（P<0.05）。治疗后，两组患者血清炎性因子白细胞介素6（IL-6）、白细胞介素17（IL-17）、肿瘤坏死因子α（TNF-α）、干扰素-γ（IFN-γ）水平均较治疗前显著降低（P<0.05）；治疗后，治疗组血清炎性因子水平显著低于对照组（P<0.05）。结论 丹青胶囊联合他扎罗汀倍他米松治疗银屑病效果明显，能显著降低炎性因子水平，并有助于改善皮损情况，值得临床推广应用。

Objective To investigate the efficacy of Danqing Capsules combined with tazarotene and betamethasone in treatment of psoriasis. Methods Methods a total of 114 patients with psoriasis treated in dermatology department of Tianjin Occupational Disease Prevention and Control Hospital from June 2019 to June 2021 were selected and divided into control group and treatment group according to random number method, with 57 cases in each group. Patients in the control group were given Tazarotene and Betamethasone Dipropionate Cream, washed the affected area, after the skin was dry, evenly applied appropriate amount of this product to the affected area, once daily. Patients in the treatment group were po administered with Danqing Capsules on the basis of the control group, 4 grains/time, three times daily. Both groups were treated for 7 d. The clinical efficacy and improvement time of clinical symptoms in two groups were observed, and the score of skin lesion area and severity index (PASI) and the level of serum inflammatory factors were compared between two groups before treatment and 1, 4, and 8 weeks after treatment. Results After treatment, the total effective rate of the treatment group was 98.25%, significantly higher than that of the control group (82.46%) (P < 0.05). After treatment, the improvement time of dark red skin, skin hypertrophy, skin pruritus, and skin pain in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, PASI score in both groups was significantly lower than that before treatment (P < 0.05). PASI score in treatment group was significantly lower than control group at 1, 4, and 8 weeks after treatment (P < 0.05). After treatment, serum levels of inflammatory cytokines interleukin-6 (IL-6), interleukin-17 (IL-17), tumor ecrosis factor α (TNF-α) and interferon -γ (IFN-γ) in two groups were significantly decreased compared with before treatment. After treatment, the level of serum inflammatory factors in treatment group was significantly lower than that in control group (P < 0.05). Conclusion Danqing Capsules combined with tazarotene and betamethasone has obvious effect in treatment of psoriasis, and can significantly reduce the level of inflammatory factors and help to improve skin lesions, which is worthy of clinical application.

R986

天津市科委重点攻关项目（CSTC2017AB5032）