[关键词]
[摘要]
目的 探讨胆木浸膏糖浆联合氧氟沙星滴耳液治疗儿童急性中耳炎的临床疗效。方法 选取2020年6月—2021年6月郑州大学附属儿童医院五官科收治的116例儿童急性中耳炎患儿,按照随机数字表法将所有患儿分为对照组和治疗组,每组各58例。对照组患儿给予氧氟沙星滴耳液滴耳,5滴/次,2次/d。治疗组患儿在对照组的治疗基础上口服胆木浸膏糖浆,10 mL/次,3次/d。两组治疗14 d。观察两组患儿的临床疗效,比较两组临床症状好转时间和血清因子水平。结果 治疗后,治疗组总有效率是98.27%,显著高于对照组的82.75%(P<0.05)。治疗组患儿耳痛、鼓膜充血、耳鸣、听力下降等症状好转时间均显著短于对照组(P<0.05)。治疗后,两组免疫球蛋白E(IgE)、白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均较治疗前显著降低(P<0.05);治疗后,治疗组患儿血清因子水平显著低于对照组(P<0.05)。结论 胆木浸膏糖浆联合氧氟沙星滴耳液治疗儿童急性中耳炎具有较好的临床疗效,有效改善患儿症状,能降低患儿炎症反应,值得临床推广应用。
[Key word]
[Abstract]
Objective To investigate the therapeutic effect of Danmujin Cream Syrup combined with Ofloxacin Ear Drops in treatment of acute otitis media in children. Methods A total of 116 children with acute otitis media treated in the Department of Ophthalmology and Otorhinolaryngology, Children's Hospital Affiliated to Zhengzhou University from June 2020 to June 2021 were selected. All the children were divided into control group and treatment group according to random number table method, with 58 cases in each group. Patients in the control group were given Ofloxacin Ear Drops, 5 drops/time, twice daily. Patients in the treatment group were po administered with Danmujin Cream Syrup on the basis of control group, 10 mL/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms and serum factor levels were compared between the two groups. Results After treatment, the total effective rate in the treatment group was 98.27%, significantly higher than that in the control group (82.75%, P < 0.05). The improvement time of earache, eardrum congestion, tinnitus, hearing loss and other symptoms in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, the levels of immunoglobulin E (IgE), interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the serum factor level in treatment group was significantly lower than that in control group (P < 0.05). Conclusion Danmujin Cream Syrup combined with Ofloxacin Ear Drops has good clinical efficacy in treatment of acute otitis media in children, and can effectively improve the symptoms of children, and can reduce the inflammatory response of children, which is worthy of clinical application.
[中图分类号]
R985;R987
[基金项目]
河南省医学科技攻关项目联合共建项目(2018020611)