目的 探讨益心舒胶囊联合替格瑞洛片治疗急性心肌梗死的临床疗效。方法 选取2020年4月—2021年8月安阳市第三人民医院收治的88例急性心肌梗死患者，根据随机数字表法将所有患者分为对照组和治疗组，各包括44例。对照组患者口服替格瑞洛片，90 mg/次，2次/d。治疗组患者在对照组基础上口服益心舒胶囊，1.2 g/次，3次/d。两组在治疗1个月后统计疗效。观察两组临床疗效，比较两组治疗前后心功能指标、血小板聚集率、血栓指标。结果 治疗后，治疗组患者的总有效率（88.64%）比对照组（70.45%）高（P<0.05）。治疗后，两组的左心室射血分数（LVEF）、每搏输出量（SV）明显升高，二尖瓣舒张早期血流峰速度与二尖瓣环舒张早期运动峰速度之比（E/Em）显著降低（P<0.05）；且治疗后治疗组的LVEF、SV高于对照组，E/Em低于对照组（P<0.05）。治疗后，两组的血小板聚集率显著降低（P<0.05），且治疗组血小板聚集率较对照组降低更明显（P<0.05）。治疗后，两组的血浆凝血酶抗凝血酶复合物（TAT）、血栓调节蛋白（TM）、纤溶酶-α₂纤溶酶抑制物复合物（PIC）均显著降低（P<0.05），且治疗组的TAT、TM、PIC降低更明显（P<0.05）。结论 益心舒胶囊联合替格瑞洛片治疗急性心肌梗死的疗效确切，能提高心功能，降低血小板聚集率，调节血小板分泌，安全性良好。

Objective To investigate the clinical efficacy of Yixinshu Capsules combined with Ticagrelor Tablets in treatment of acute myocardial infarction. Methods Patients (90 cases) with acute myocardial infarction in Anyang Third People's Hospital from April 2020 to August 2021 were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were po administered with Ticagrelor Tablets, 90 mg/time, twice daily. Patients in the treatment group were po administered with Yixinshu Capsules on the basis of the control group, 1.2 g/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and cardiac function index, platelet aggregation rate, and thrombus index in two groups were compared. Results After treatment, the total effective rate of the treatment group (88.64%) was higher than that of the control group (70.45%) (P < 0.05). After treatment, the LVEF and SV in two groups were significantly increased, but the E/Em in two groups were significantly decreased (P < 0.05). After treatment, the LVEF and SV in the treatment group were higher than those in the control group, but the E/Em in the treatment group was lower than those in the control group (P < 0.05). After treatment, the platelet aggregation rate of two groups were significantly decreased (P < 0.05), and the platelet aggregation rate of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the TAT, TM, and PIC of two groups were significantly decreased (P < 0.05), and the TAT, TM, and PIC of the treatment group were significantly lower than those of the control group (P< 0.05). Conclusion Yixinshu Capsules combined with Ticagrelor Tablets is effective in treatment of acute myocardial infarction, which can improve cardiac function, reduce platelet aggregation rate, and regulate platelet secretion, with good drug safety.

R972

河南省医学科技攻关计划（联合共建）项目（LHGJ20191277）