白芍总苷可以改善动脉粥样硬化程度和心肌重构、减轻心肌缺血、缩小心肌梗死面积、减轻心肌缺血再灌注损伤，具有心肌和血管保护作用，其机制与调节血脂、抗血小板聚集、抑制氧化应激、减轻炎症损伤、抑制细胞凋亡/焦亡相关。通过系统梳理文献，深入探讨白芍总苷的心血管保护效应及其作用机制，为白芍总苷防治心血管疾病提供新策略。

Total glucoside of paeony (TGP) can improve the degree of atherosclerosis and myocardial remodeling, relieve myocardial ischemia, decrease the size of myocardial infarction, reduce myocardial ischemia-reperfusion injury, and has myocardial and vascular protective effects. Its mechanism is related to regulating blood lipid, anti-platelet aggregation, inhibiting oxidative stress, reducing inflammatory injury and inhibiting apoptosis / pyroptosis. Through systematic review of literature reports, this article discusses in depth the cardiovascular protective effects of TGP and its mechanism of action, and provides a new strategy for TGP to prevent and treat cardiovascular diseases.

R972

天津市卫生计生行业高层次人才选拔培养工程；中华中医药学会青年人才托举工程项目（CACM-2018-QNRC2-B04）