偏头痛是一种临床常见的原发性头痛疾病，其发病率、致残率逐年升高，给患者、家庭和社会带来沉重负担。目前偏头痛发病机制尚不明确。有研究表明压力、睡眠障碍等与偏头痛周期性发作有密切联系。褪黑激素在临床上广泛应用，尤其在其节律性减少或失调有关的疾病中，如昼夜节律性睡眠障碍、阿尔茨海默病等。偏头痛患者被证明存在时间生物学功能障碍，并且褪黑激素被证明具有抗炎、抗氧化、抗焦虑、镇痛等作用，因此对褪黑激素治疗偏头痛的作用机制和临床应用研究进展进行概括，以期为偏头痛的防治提供参考。

Migraine is a common clinical primary headache disease. Its incidence and disability rate are increasing year by year, which brings a heavy burden to patients, families, and society. At present, the pathogenesis of migraine is still unclear. Studies have shown that stress, sleep disturbance, etc. are closely related to the periodic attacks of migraine. Melatonin is widely used in clinics, especially in diseases related to its rhythmic reduction or imbalance, such as circadian rhythm sleep disorder, Alzheimer's disease, and so on. Patients with migraine have been proved to have chronobiological dysfunction, and melatonin has been shown to have anti- inflammatory, antioxidant, anti-anxiety, and analgesic effects. This article discusses the mechanism and clinical application of melatonin in treatment of migraine, which provides reference for the prevention and treatment of migraine.

R971

山东省医药卫生科技发展计划项目（2019WS322）