通过查阅文献和总结管理实践，归纳了影响用药安全的潜在风险因素和管理实践需关注的要点，为临床实践提供参考。用药错误、药品不良反应、超说明书用药以及药品质量缺陷是威胁用药安全的潜在风险因素。医疗机构用药安全的影响因素众多，除了与药物本身相关外，用药安全还与患者、医务工作者、工作流程、工作环境、药学设备和管理等因素有关。结合管理实践经验，用药安全的管理需要全员参与、全面覆盖，从人员、流程、硬件、软件和环境等多方面查漏补缺、持续改进，才能筑牢医疗机构用药安全的防线。

The potential risk factors that affecting drug safety were systematically summarized through literature review, and the key points of corresponding management practice were also summarized, to provide reference for clinical practice. Medication errors, adverse drug reactions, off-label drug use, and drug quality defects are potential risk factors of drug safety. There are many factors influencing drug safety in medical institutions, in addition to the drug itself, patients, medical workers, workflow, work environment, pharmaceutical equipment, and the management are all factors that relevant to drug safety, which needs full participation and full process management. With the rich experience in management practice, we should find out the potential problems from personnel, processes, hardware, software and work environment, then make continuous improvement, in order to ensure the safety of patients.

R951

国家自然科学基金青年科学基金项目（82104310）；北京医卫健康公益基金会医学科学研究基金项目（B20199FN）