目的 分析泰达国际心血管病医院心血管疾病患者发生血流感染的病原菌分布及耐药特征，为临床合理应用抗菌药物提供依据。方法 对2012年1月—2020年12月泰达国际心血管病医院血流感染病原菌的分布及耐药性进行回顾性分析。结果 共检出病原菌234株，其中革兰阴性菌133株，构成比为56.8%，主要为大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌；革兰阳性菌95株，构成比为40.6%，主要为凝固酶阴性葡萄球菌、草绿色链球菌和金黄色葡萄球菌；真菌6株，构成比为2.6%。大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌对碳青霉烯类和阿米卡星保持高度敏感。葡萄球菌属中，凝固酶阴性葡萄球菌中甲氧西林耐药菌株检出率显著高于金黄色葡萄球菌。未发现耐利奈唑胺、万古霉素和替考拉宁革兰阳性菌。结论 泰达国际心血管病医院心血管疾病患者血流感染的病原菌主要以革兰阴性菌为主，应加强血流感染病原菌的耐药性监测，为临床医生经验用药提供依据。

Objective To investigate the distribution and drug resistance of bloodstream infection pathogens in cardiovascular patients in TEDA International Cardiovascular Hospital, and to provide evidence for rational use of antibiotics.Methods The distribution and drug resistance of bloodstream infection pathogens in TEDA International Cardiovascular Hospital were retrospectively analyzed from January 2012 to December 2020.Results Total 234 strains of bloodstream infection pathogens were isolated. Gram-negative bacteria (133 strains) accounted for 56.8%, and main of them were Escherichia coli, Klebsiella pneumonia, and Enterobacter cloacae. Gram-positive bacteria were 95 strains (40.6%), and main of them were coagulase negative Staphylococcus, Viridans streptococcus, and Staphylococcus aureus. Fungi were 6 strains, accounting for 2.6%. Escherichia coli, Klebsiella pneumonia, and Enterobacter cloacae were highly sensitive to carbapenems and amikacin. Among Staphylococcus, the detection rate of methicillin resistant coagulase negative Staphylococcus was higher than that of Staphylococcus aureus. No Gram-positive bacteria was resistant to linezolid, vancomycin, and teicopalnin.Conclusions Gram-negative bacteria are the main pathogens of bloodstream infection in cardiovascular patients in TEDA International Cardiovascular Hospital. It is necessary to strengthen surveillance of drug resistance of pathogens in bloodstream infection, in order to provide evidence for clinical doctors to use drugs empirically.

R978.1