目的 调查分析2018—2020年天津市津南医院抗脑血管病药的应用情况及趋势，为医院抗脑血管病药的科学管理和合理应用提供参考。方法 采用数据回顾性方法，对天津市津南医院抗脑血管病药的用药总金额、用药总数量及构成比、限定日计量（DDD）值、用药频度（DDDs）及日均费用（DDC）等数据进行统计与分析。结果 天津市津南医院共有24种抗脑血管病药，抗脑血管病药的销售金额逐年下降。2018—2019年，口服抗脑血管病药中口服水解蛋白、胞磷胆碱钠片和长春西汀片（5 mg）的销售金额排名始终排名前3位，且2020年胞磷胆碱钠片的销售金额排名居首位。注射用抗脑血管病药中除2019年的银杏叶提取物注射液，丁苯酞氯化钠注射液、奥拉西坦注射液、银杏叶提取物注射液的销售金额排名始终居前3位。口服抗脑血管病药中除了2020年的奥拉西坦胶囊，奥拉西坦胶囊、盐酸氟桂利嗪胶囊、胞磷胆碱钠片的DDDs排名始终居前3位。注射用抗脑血管病药中除了2020年的注射用七叶皂苷钠（10 mg）和2019年的银杏叶提取物注射液，其他时间二者的DDDs排名均在前2位。2018—2020年，除了口服水解蛋白DDC值高于50元外，其他口服抗脑血管病药的DDC均低于10元。2018—2020年，除了丁苯酞氯化钠注射液和注射用奥拉西坦DDC值高于200元，其他类注射用抗脑血管病药的DDC值均低于200元。结论 天津市津南医院抗脑血管病药的管理比较规范，药物使用大致合理。

Objective To investigate and analyze the application and trend of anti-cerebrovascular disease drugs in Tianjin Jinnan Hospital from 2018 to 2020, so as to provide references for the scientific management and rational application of anti-cerebrovascular disease drugs in Tianjin Jinnan Hospital.Methods Data retrospective method was used to calculate the total amount of anti-cerebrovascular disease drugs used in Tianjin Jinnan Hospital. The total consumption sum, total quantity and composition ratio, DDD value, DDDs and DDC of anti-cerebrovascular drugs in Tianjin Jinnan Hospital were analyzed statistically.Results There are 24 kinds of anti-cerebrovascular disease drugs in Tianjin Jinnan Hospital. The sales amounts of anti-cerebrovascular disease drugs were decreasing year by year. From 2018 to 2019, the sales amounts of Oral Protein Hydrolysate, Citicoline Sodium Tablets, and Vinpocetine Tablets (5 mg) always ranked the top 3, and the consumption sum of Citicoline Sodium Tablets ranked the first in 2020. In addition to Extract of Ginkgo Biloba Leaves Injection in 2019, the sales value of Butylphthalide and Sodium Chloride Injection, Oxiracetam Injection, and Extract of Ginkgo Biloba Leaves Injection always ranked the top 3. In addition to the DDDs of Oxiracetam Capsules in 2020, the DDDs of Oxiracetam Capsules, Flunarizine Hydrochloride Capsules, and Citicoline Sodium Tablets always ranked the top 3. Except for Sodium Aescinate for injection (10 mg) in 2020 and Extract of Ginkgo Biloba Leaves Injection in 2019, the DDDs of both of them ranked top 2 in other times. From 2018 to 2020, DDC values of other oral anti-cerebrovascular drugs were all less than 10 yuan, except DDC values of Oral Protein Hydrolysate were higher than 50 yuan. From 2018 to 2020, the DDC values of other anti-cerebrovascular diseases drugs for injection were all lower than 200 yuan, except that the DDC values of Butylphthalide and Sodium Chloride Injection and Oxiracetam for Injection were higher than 200 yuan.Conclusion The management of anti-cerebral vascular drugs in Tianjin Jinnan Hospital is relatively standardized, and the use of drugs is generally reasonable.

R971

国家自然科学基金青年项目（8180130669）