目的 探讨胃康灵胶囊联合雷贝拉唑钠肠溶片治疗胃溃疡的临床疗效。方法 选取2018年1月—2020年12月在濮阳市中医医院进行治疗的82例胃溃疡患者为研究对象，根据用药不同将所有患者分为对照组和治疗组，每组各41例。对照组口服雷贝拉唑钠肠溶片，20 mg/次，1次/d；治疗组在对照组基础上口服胃康灵胶囊，1.6 g/次，3次/d。两组均连续治疗6周比较效果。观察两组临床疗效，比较两组临床症状改善时间、胃肠激素水平和血清学指标。结果 经治疗，治疗组总有效率是97.56%，显著高于对照组的80.49%（P＜0.05）。经治疗，治疗组胃脘痛、纳差、反酸、胃寒喜温等中医证候改善时间均显著短于对照组（P＜0.05）。经治疗，两组血清白细胞介素-6（IL-6）、白细胞介素-17（IL-17）、基质金属蛋白酶-9（MMP-9）、降钙素原（PCT）水平均较治疗前显著降低，但表皮生长因子（EGF）均显著升高（P＜0.05）；且治疗后，治疗组血清炎症因子水平改善优于对照组（P＜0.05）。经治疗，两组血清胃动素（MTL）均较治疗前显著升高，但血清胃泌素（GAS）降低（P＜0.05）；治疗后，治疗组胃肠激素水平改善优于对照组（P＜0.05）。结论 胃康灵胶囊联合雷贝拉唑治疗胃溃疡具有较好的临床疗效，不仅可降低机体促炎因子水平，还可改善机体胃肠激素水平和临床症状，有着良好临床应用价值。

Objective To investigate the clinical efficacy of Weikangling Capsules combined with rabeprazole in treatment of gastric ulcer.Methods A total of 82 patients with gastric ulcer treated in Puyang Hospital of Traditional Chinese Medicine from January 2018 to December 2020 were selected as the research subjects. According to different medication, all patients were divided into control group and treatment group, with 41 cases in each group. Patients in the control group were po administered with Rabeprazole Sodium Enteric-coated Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Weikangling Capsules on the basis of the control group, 1.6 g/time, three times daily. The two groups were treated for 6 weeks to compare the effect. The clinical efficacy of the two groups was observed, and the improvement time of clinical symptoms, gastrointestinal hormone levels and serological indicators were compared between the two groups.Results After treatment, the total effective rate of the treatment group was 97.56%, significantly higher than that of the control group 80.49% (P < 0.05). After treatment, the improvement time of epigastric pain, poor appetite, acid reflux, cold and warm stomach syndrome in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, serum levels of interleukin-6 (IL-6), interleukin-17 (IL-17), matrix metalloproteinase-9 (MMP-9) and procalcitonin (PCT) in two groups were significantly decreased compared with before treatment, but epidermal growth factor (EGF) was significantly increased (P < 0.05). After treatment, the level of serum inflammatory factors in the treatment group was better than that in the control group (P < 0.05). After treatment, serum motilin (MTL) in both groups was significantly increased compared with before treatment, but serum gastrin (GAS) was decreased (P < 0.05). After treatment, the level of gastrointestinal hormone in the treatment group was better than that in the control group (P < 0.05).Conclusion Weikangling Capsules combined with rabeprazole has good clinical effect in treatment of gastric ulcer, and can not only reduce the level of proinflammatory factors, but also improve the level of gastrointestinal hormones and clinical symptoms, which has good clinical application value.

R975

河南省中医药科学研究专项课题（20-21ZY2192）