目的 观察小儿咳喘灵泡腾颗粒联合吸入用布地奈德混悬液治疗小儿喘息性肺炎的临床疗效。方法 选取2018年8月—2021年2月河南科技大学第一附属医院收治的126例小儿喘息性肺炎，根据入院就诊顺序单双号将所有患者分为对照组和治疗组，每组各63例。对照组患儿雾化吸入吸入用布地奈德混悬液，1 mg/次，2次/d。治疗组在对照组的基础上口服小儿咳喘灵泡腾颗粒，2次/d，5~7岁为2 g，2~4岁为1.5 g，＜2岁者为1 g。两组患儿均治疗2周。观察两组治疗后的疗效，比较两组患儿症状消失时间、血清免疫因子和血清炎性因子。结果 治疗后，治疗组的总有效率为90.48%，高于对照组的总有效率71.43%，组间对比存在统计学意义（P＜0.05）。治疗后，治疗组咳嗽、气促、喘息、湿啰音、哮鸣音消失时间均明显短于对照组（P＜0.05）。治疗后，两组患儿嗜酸粒细胞阳离子蛋白（ECP）、嗜酸粒细胞（EoS）水平较治疗前降低（P＜0.05），且治疗组ECP、EoS水平低于对照组（P＜0.05）。治疗后，两组白细胞介素-6（IL-6）、C反应蛋白（CRP）水平较治疗前降低，γ-干扰素（TNF-γ）水平较治疗前升高（P＜0.05）；治疗后治疗组IL-6、CRP水平低于对照组，TNF-γ水平高于对照组（P＜0.05）。结论 小儿咳喘灵泡腾颗粒联合吸入用布地奈德混悬液治疗小儿喘息性肺炎具有较好的临床疗效，可明显改善临床症状，减轻气道炎症反应。

Objective To observe the clinical effect of Xiaoer Kechuanling Effervescent Granules combined with Budesonide Suspension for inhalation in treatment of asthmatic pneumonia in children.Methods Children (126 cases) with asthmatic pneumonia in the First Affiliated Hospital of Henan University of Science and Technology from August 2018 to February 2021 were divided into control and treatment groups according to the order of the odd and even numbers of admission, and each group had 63 cases. Patients in the control group were atomization inhalation with Budesonide Suspension for inhalation, 1 mg/time, twice daily. Patients in the treatment group were po administered with Xiaoer Kechuanling Effervescent Granules on the basis of the control group, 2 g for 5 — 7 years old, 1.5 g for 2 — 4 years old, and 1 g for < 2 years old, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the disappearance time of symptoms, the serum immune factors, and the serum inflammatory factors in two groups were compared.Results After treatment, the total effective rate of the treatment group was 90.48%, which was higher than 71.43% of the control group, and there was significant difference between two groups (P < 0.05). After treatment, the disappearance time of cough, short-breath, wheezing, wet rale, and wheezing sound in the treatment group was significantly shorter than those in the control group (P < 0.05). After treatment, the levels of ECP and EoS in two groups were lower than those before treatment (P < 0.05), and the levels of ECP and EoS in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of IL-6 and CRP in two groups were lower than those before treatment, but the level of TNF-γ in two groups was higher than that before treatment (P < 0.05). After treatment, the levels of IL-6 and CRP in the treatment group were lower than those in the control group, but the level of TNF-γ was higher than that in the control group (P < 0.05).Conclusion Xiaoer Kechuanling Effervescent Granules combined with Budesonide Suspension for inhalation has clinical curative effect in treatment of asthmatic pneumonia in children, can significantly improve clinical symptoms and reduce airway inflammatory response.

R974

河南省科技发展计划项目（182102311201）