[关键词]
[摘要]
目的 探讨天舒胶囊联合氟桂利嗪治疗前庭性偏头痛的临床效果。方法 选取2019年1月—2021年6月天津市第三中心医院分院中医科诊治的120例前庭性偏头痛患者,按随机数字表法分为对照组和治疗组,每组各60例。对照组患者口服盐酸氟桂利嗪胶囊,10 mg/次,1次/d。治疗组在对照组基础上口服天舒胶囊,4粒/次,3次/d。两组疗程均为12周,随访期为8周。观察两组的临床疗效,比较两组眩晕视觉模拟评分(VAS)、临床症状、眩晕障碍量表(DHI)和脑血流速度。结果 治疗后,治疗组明显改善率是73.3%,明显高于对照组的33.3%(P<0.05)。治疗后,两组VAS评分均显著降低,眩晕平均每月发作次数与持续时间均显著减少(P<0.05);治疗后,治疗组VAS评分和临床症状改善均优于对照组(P<0.05)。治疗后,两组躯体评分、情绪评分、功能评分及DHI总分均显著降低(P<0.05);治疗后,治疗组DHI评分显著低于对照组(P<0.05)。治疗后,两组大脑椎动脉(VA)和基底动脉(BA)的平均血流速度均显著降低(P<0.05);治疗后,治疗组VA和BA的平均血流速度均低于对照组(P<0.05)。结论 天舒胶囊联合氟桂利嗪治疗前庭性偏头痛疗效良好,可改善临床症状,缩减发作频率及发作时间,在躯体及情绪维度提升患者生活质量,值得临床推广。
[Key word]
[Abstract]
Objective To investigate the effect of Tianshu Capsules combined with flunarizine in treatment of vestibular migraine.Methods A total of 120 patients with vestibular migraine treated in the Department of Traditional Chinese Medicine of Tianjin Third Central Hospital Branch from January 2019 to June 2021 were selected and divided into control group and treatment group according to random number table method, with 60 cases in each group. Patients in the control group were po administered with Flunarizine Hydrochloride Capsules, 10 mg/time, once daily. Patients in the treatment group were po administered with Tianshu Capsules on the basis of the control group, 4 grains/time, three times daily. The treatment course of both groups was 12 weeks, and the follow-up period was 8 weeks. After treatment, the clinical efficacy was evaluated, visual analogue scale (VAS), clinical symptoms, vertigo disorder scale (DHI) and cerebral blood flow velocity were compared between the two groups.Results After treatment, the improvement rate of the treatment group was 73.3%, which was significantly higher than that of the control group (33.3%, P < 0.05). After treatment, VAS scores were significantly decreased in both groups, and the average number and duration of vertigo attacks per month were significantly decreased in both groups (P < 0.05). After treatment, VAS score and clinical symptoms in the treatment group were better than those in the control group (P < 0.05). After treatment, body score, mood score, functional score, and DHI total score in two groups were significantly decreased (P < 0.05). After treatment, DHI score in treatment group was significantly lower than that in control group (P < 0.05). After treatment, the mean blood flow velocity of cerebral vertebral artery (VA) and basilar artery (BA) was significantly decreased in both groups (P < 0.05). After treatment, the average blood flow velocity of VA and BA in treatment group was lower than that in control group (P < 0.05).Conclusion Tianshu Capsules combined with flunarizine has good efficacy in treatment of vestibular migraine, and can improve clinical symptoms, reduce the frequency and duration of attacks, and improve the life quality of patients in physical and emotional dimensions, which is worthy of clinical promotion.
[中图分类号]
R971
[基金项目]
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015020)