目的 分析天津市津南医院平喘药的应用情况和趋势，为临床合理用药提供参考。方法 对2018—2020年天津市津南医院平喘药的应用品种、销售金额、用药频度（DDDs）及日均药费（DDC）进行统计和分析。结果 天津市津南医院平喘类药物包括β肾上腺素受体激动剂、M胆碱受体拮抗剂、黄嘌呤类药物、肾上腺皮质激素、抗白三烯类药物和中成药6大类。2018—2020年医院平喘药的销售金额呈先上升后下降的趋势，在销售金额及构成比中，β肾上腺素受体激动剂、肾上腺皮质激素这2类平喘类药物所占比例排名前2位，其中β肾上腺素受体激动剂的销售金额构成比每年均大于34%。2018—2020年销售金额排名前15名的平喘类药物主要是β肾上腺素受体激动剂，其次是中成药类药物和肾上腺皮质激素。2018—2020年DDDs排名前15位的平喘药主要是β肾上腺素受体激动剂，其次是中成药类药物和抗白三烯类药物，β肾上腺素受体激动剂复方甲氧那明胶囊在2018—2020年均位居DDDs首位。沙美特罗替卡松粉吸入剂（550 μg）DDC居首位，其他平喘类药物DDC基本无变化。医院部分平喘类药品的B/A基本接近1.00。结论 天津市津南医院平喘类药物品种齐全，使用基本合理，但个别药品的选择和使用上存在不合理用药现象，提示临床医师在指导哮喘患者应用平喘类药物时应严格明确用药指征，实现个体化用药，达到长期稳定控制哮喘的目的。

Objective To analyze the application and trend of antiasthmatic drugs in Tianjin Jinnan Hospital, and provide references for clinical rational use of drugs. Methods The application varieties, sales amount, frequency of medication (DDDs) and average daily drug costs (DDC) of antiasthmatic drugs from 2018 to 2020 were statistically and analyzed. Results The antiasthmatic drugs in our hospital include β-adrenergic receptor agonists, M-choline receptor antagonists, xanthines, adreno cortico hormones, anti- leukotriene drugs, and Chinese patent medicines. From 2018 to 2020, the sales amount of antiasthmatic drugs in our hospital will increase first and then decline. In terms of sales amount and composition, the proportion of β-adrenergic receptor agonists and adreno cortico hormones took the top two places in the proportion of antiasthmatic drugs, the sales amount of β-adrenergic receptor agonists accounted for more than 34% each year. The top 15 antiasthmatic drugs in sales from 2018 to 2020 are mainly β-adrenergic receptor agonists, followed by proprietary Chinese medicines and adreno cortico hormones. The top 15 antiasthmatic drugs in DDDs from 2018 to 2020 are mainly β-adrenergic receptor agonists, followed by Chinese patent medicines and anti-leukotriene drugs, and β-adrenergic receptor agonist Compound Methoxyphenamine Capsules ranked first in DDDs from 2018 to 2020. The DDC of Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation (550 μg) was the first, while the DDC of other antiasthmatic drugs had little change. The B/A of some antiasthmatic drugs in hospital was basically close to 1.00. Conclusion Tianjin Jinnan Hospital has a complete variety of antiasthmatic drugs, and the use of antiasthmatic drugs is basically reasonable. However, there is irrational use phenomenon in selection and use of some drugs, suggesting that clinicians should strictly clarify the indication of medication when guiding the use of antiasthmatic drugs, so as to achieve the purpose of individualized medication and long-term stable control of asthma.

R974

国家自然科学基金青年基金项目（8180130669）