目的 探讨齿痛消炎灵颗粒联合盐酸米诺环素软膏治疗慢性牙周炎的临床疗效。方法 选取2018年2月—2021年5月在武警河南总队医院治疗的124例慢性牙周炎患者，根据随机数字表法将患者分为对照组和治疗组，每组各62例。对照组给予盐酸米诺环素软膏治疗，注满患部牙周袋内，以溢出为宜，1次/周。治疗组在对照组治疗基础上口服齿痛消炎灵颗粒，10 g/次，3次/d。两组均连续治疗4周。观察两组临床疗效，比较两组牙周指标、血清炎症指标。结果 治疗后，对照组的总有效率为72.58%，明显低于治疗组的91.94%（P<0.05）。治疗后，两组出血指数（BI）、牙周袋深度（PD）、牙龈指数（GI）、龈沟出血指数（SBI）、菌斑指数（PLI）较同组治疗前降低（P<0.05），且治疗组BI、PD、GI、SBI、PLI明显低于对照组（P<0.05）。治疗后，两组白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、高迁移率族蛋白B（HMGB）水平较同组治疗前降低（P<0.05），且治疗组IL-6、TNF-α、HMGB水平明显低于对照组（P<0.05）。结论 齿痛消炎灵颗粒联合盐酸米诺环素软膏可有效改善慢性牙周炎患者的临床症状，抑制炎症因子水平分泌，安全性较好。

Objective To investigate the clinical effect of Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment in treatment of chronic periodontitis. Methods Patients (124 cases) with chronic periodontitis in Henan Armed Police Corps Hospital from February 2018 to May 2021 were randomly divided into control and treatment groups, and each group had 62 cases. Patients in the control group were given Minocycline Hydrochloride Ointment, filled the affected periodontal pocket, and overflow, once daily. Patients in the treatment group were po administered with Chitong Xiaoyanling Granules on the basis of the control group, 10 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the periodontal indexes and serum inflammatory indexes in two groups were compared. Results After treatment, the total effective rate in the control group was 72.58%, which was significantly lower than 91.94% in the treatment group (P < 0.05). After treatment, the BI, PD, GI, SBI, and PLI in two groups were lower than those in the same group before treatment (P < 0.05), and the BI, PD, GI, SBI, and PLI in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of IL-6, TNF-α, and HMGB in two groups were lower than those in the same group before treatment (P < 0.05), and the levels of IL-6, TNF-α, and HMGB in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment can effectively improve the clinical symptoms of patients with chronic periodontitis, and inhibit the secretion of inflammatory factors, with good safety.

R988.2

河南省重点研发与推广专项项目（212102310593）