目的 探讨止喘灵口服液联合沙丁胺醇治疗儿童喘息性支气管炎的临床疗效。方法 选择2019年4月—20121年4月在周口市中心医院治疗的106例喘息性支气管炎患儿，根据用药的差别分为对照组和治疗组，每组各53例。对照组雾化吸入硫酸沙丁胺醇雾化吸入溶液，0.5 mL/次加入生理盐水2 mL，4次/d；治疗组在对照组基础上口服止喘灵口服液，10 mL/次，3次/d。两组均经1周治疗。观察两组患儿临床疗效，比较治疗前后两组患儿临床症状改善时间，肺功能指标第1秒用力呼气量（FEV₁）、第1秒用力呼气量预计值百分比（FEV₁%）和第1秒用力呼气量占所有呼气量的比例（FEV₁/FVC），及炎症介质可溶性细胞间黏附分子-1（sICAM-1）、嗜酸细胞阳离子蛋白（ECP）、白细胞介素-6（IL-6）、半胱氨酰白三烯（CysLTs）和白细胞介素-17（IL-17）水平。结果 经治疗，对照组和治疗组总有效率分别为84.91%和98.11%（P<0.05）。经治疗，治疗组患儿临床症状改善时间明显早于对照组（P<0.05）。经治疗，两组患儿FEV₁、FEV₁%、FEV₁/FVC均明显升高（P<0.05），且治疗组升高更明显（P<0.05）。经治疗，两组血清sICAM-1、ECP、IL-6、CysLTs、IL-17水平均明显下降（P<0.05），且治疗组下降最明显（P<0.05）。结论 硫酸沙丁胺醇联合止喘灵口服液治疗儿童喘息性支气管炎不但促使患儿症状改善，而且有利于肺功能及促炎因子的改善。

Objective To investigate the clinical efficacy of Zhichuanling Oral Liquid combined with salbutamol in treatment of asthmatic bronchitis in children. Methods Children (106 cases) with asthmatic bronchitis in Zhoukou Central Hospital from April 2019 to April 2021 were divided into control and treatment groups according to the difference of medication, and each group had 53 cases. Children in the control group were atomization inhalation administered with Salbutamol Sulfate Nebules Inhalation Solution, 0.5 mL/time added into normal saline 2 mL, four times daily. Children in the treatment group were po administered with Zhichuanling Oral Liquid, 10 mL/time, three times daily. Children in two groups were treated for 1 week. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, the lung function indexes FEV₁, FEV₁%, and FEV₁/FVC, and the levels of inflammatory mediators ICAM-1, ECP, IL-6, CysLTs, and IL-17 in two groups before and after treatment were compared. Results After treatment, the clinical effective rates of the control group and the treatment group were 84.91% and 98.11% respectively (P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, FEV₁, FEV₁%, and FEV₁/FVC in two groups were significantly increased (P < 0.05), and the increase was more obvious in the treatment group (P < 0.05). After treatment, the levels of serum sICAM-1, ECP, IL-6, CysLTs, and IL-17 in two groups were significantly decreased (P < 0.05), and the decrease was the most obvious in the treatment group (P < 0.05). Conclusion Zhichuanling Oral Liquid combined with salbutamol in treatment of asthmatic bronchitis in children can not only improve the symptoms of children, but also improve the lung function and pro-inflammatory factors.

R974;R985

河南省医学科技攻关计划项目（LHGJ20200649）