[关键词]
[摘要]
目的 探讨虫草清肺胶囊联合布地奈德福莫特罗治疗慢性喘息性支气管炎的临床疗效。方法 选取2019年2月—2021年2月在天津市宁河区医院诊治的188例慢性喘息性支气管炎患者,随机分为对照组(94例)和治疗组(94例)。对照组患者吸入布地奈德福莫特罗吸入粉雾剂,2吸/次,2次/d。治疗组患者在对照组的基础上口服虫草清肺胶囊,3粒/次,3次/d。两组患者连续治疗7 d。观察两组患者临床疗效,比较治疗前后两组患者临床症状好转时间、动脉血酸碱度(pH)、动脉血氧分压(pO2)、动脉血二氧化碳分压(pCO2),及血清炎性因子白细胞介素8(IL-8)、白细胞介素6(IL-6)和肿瘤坏死因子-α(TNF-α)水平。结果 治疗后,治疗组患者总有效率明显高于对照组(98.93%vs 87.23%,P<0.05)。治疗后,治疗组患者临床症状好转时间均明显早于对照组(P<0.05)。治疗后,两组患者血气pH值、pO2均明显高于治疗前,pCO2明显低于治疗前(P<0.05),且治疗组患者pH值、pO2、pCO2明显好于对照组(P<0.05)。治疗后,两组患者血清炎性因子IL-8、IL-6、TNF-α水平明显降低(P<0.05),且治疗组患者明显低于对照组(P<0.05)。结论 虫草清肺联合布地奈德福莫特罗治疗慢性喘息性支气管炎临床疗效好,能有效改善症状,降低炎性反应。
[Key word]
[Abstract]
Objective To investigate the clinical study of Chongcao Qingfei Capsules combined with budesonide formoterol in treatment of chronic asthmatic bronchitis. Methods Patients (188 cases) with chronic asthmatic bronchitis in Tianjin Ninghe Hospital from February 2019 to February 2021 were randomly divided into control (94 cases) and treatment (94 cases) groups. Patients in the control group were inhalation administered with Budesonide and Formoterol Fumarate Powder for inhalation, 2 press/time, twice daily. Patients in the treatment group were po administered with Chongcao Qingfei Capsules, 3 grains/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, pH, pO2, pCO2, and the levels of serum inflammatory factor in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (98.93% vs 87.23%, P< 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the pH of blood gas and pO2 in two groups were significantly higher than those before treatment, but the pCO2 was significantly lower than that of the control group (P < 0.05), and pH, pO2 and pCO2 in the treatment group were significantly better than those in the control group. After treatment, the levels of serum inflammatory factors IL-8, IL-6, and TNF-α in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion The clinical effect of Chongcao Qingfei Capsules combined with budesonide formoterol in treatment of chronic asthmatic bronchitis is remarkable, which can effectively improve the symptoms and reduce the inflammatory reaction.
[中图分类号]
R974
[基金项目]
河北省中医药管理局科研计划项目(2019311)