药物的心脏毒性研究已经成为药物临床安全性评价的一项重要内容。随着上市药物的逐步增多，心脏毒性药物不良反应的报道也呈现上升趋势，近年来药物心脏毒性评价的研究也越来越受到国内外学者的青睐，但是药物心脏毒性评价还没有建立一套客观准确的体外方法。拟全面归纳了心脏毒性药物的分类，整合了药物心脏毒性评价的方法，并对药物心脏毒性评价新技术进行了介绍，为心脏毒性药物的安全性评价工作的开展提供了思路。

The study of drug cardiotoxicity has become an important part of the clinical safety evaluation of drugs. With the gradual increase of marketed drugs, the reports of adverse reactions of cardiotoxic drugs have also shown an upward trend. In recent years, research on drug cardiotoxicity evaluation has also been favored by scholars at home and abroad. However, an objective set of drug cardiotoxicity evaluation has not yet been established. This article comprehensively summarizes the classification of cardiotoxic drugs, integrates the methods of drug cardiotoxicity evaluation, and introduces new technologies for drug cardiotoxicity evaluation, which provides ideas for the development of the safety evaluation of cardiotoxic drugs.

R972

国家自然科学基金青年科学基金项目（81700183）；天津医科大学肿瘤医院科研项目（1810）