目的 了解南方医科大学附属东莞医院莫西沙星药品不良反应（ADR）的特点及有关因素，为莫西沙星的临床合理用药治疗提供一定的参考。方法 对南方医科大学附属东莞医院2016—2019年医院电子病历系统收录的莫西沙星的药品不良反应病例进行回顾性的分析总结，分析不良反应的规律及其相关因素。结果 共收集5 986例莫西沙星药物使用病例，关于不良反应的有132例；其中一般ADR出现119例（90.15%），严重ADR出现13例（9.85%）；ADR主要发生在36～59岁和≥60岁的中老年患者；静脉给药的有129例（97.73%），口服给药的有3例（2.27%）。ADR涵盖了皮肤及其附件系统、神经系统、消化系统、心血管系统；发生ADR后，患者停药处理后均痊愈或好转，无出现后遗症患者。结论 莫西沙星的ADR发生率较少，严重ADR发生率较低，但存在着新的ADR，临床医护人员应该有着足够的重视，确保安全、合理地使用该药。

Objective To understand the characteristics and related factors of adverse drug reactions (ADR) of moxifloxacin in Dongguan Hospital affiliated to Southern Medical University, to provide some reference for the clinical rational drug use of moxifloxacin. Methods The adverse drug reactions (ADR) cases of moxifloxacin recorded in the electronic medical record system of Dongguan Hospital affiliated to Southern Medical University from 2016 to 2019 were retrospectively analyzed and summarized, and the rule of adr and its relationship with related factors were analyzed Results A total of 5 986 cases of moxifloxacin use were collected, including 132 cases of adverse reactions. There were 119 cases (90.15%) of general ADR, and 13 cases (9.85%) of severe ADR. Adverse reactions mainly occurred in middle-aged and elderly patients aged 36 — 59 years and ≥ 60 years old. 129 cases (97.73%) were given intravenously, and 3 cases (2.27%) were given orally. Adverse reactions include skin and its accessory system, nervous system, digestive system and cardiovascular system. After adverse reactions occurred, all patients were cured or improved after drug withdrawal, and no sequelae occurred. Conclusion The incidence of moxifloxacin adverse reactions was relatively low, and the incidence of severe ADR was relatively low. But there are new adverse reactions. The clinical medical staff should still have enough attention, to ensure the safe and reasonable use of this drug.

R978.1

广东省医学科研基金资助项目（B2020086）；广东省医院药学研究基金（澳美基金）资助项目（2021A08）