[关键词]
[摘要]
目的 探讨尿毒清颗粒联合他克莫司胶囊治疗肾病综合征的临床疗效。方法 选取2019年1月—2020年12月驻马店市中心医院收治的94例医院肾病综合征患者资料进行回顾性分析,所有患者随机分为对照组和治疗组,每组各47例。对照组口服他克莫司胶囊,0.05 mg/kg,1次/d,控制血药浓度维持在10 ng/mL。治疗组在对照组治疗的基础上每日6:00、12:00、18:00时口服尿毒清颗粒,5 g/次,每日22:00时口服尿毒清颗粒10 g。两组患者持续治疗2个月。观察两组的临床疗效,比较两组治疗前后的肾功能、脂代谢。结果 治疗后,治疗组患者的总有效率为93.62%,高于对照组的总有效率78.72%(P<0.05)。治疗后,两组肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白定量(24 h Upro)水平均降低(P<0.05),且治疗组Scr、BUN、24 h Upro水平低于对照组(P<0.05)。治疗后,两组三酰甘油(TG)水平均降低,高密度脂蛋白胆固醇(HDL-C)水平均升高(P<0.05);且治疗组TG水平低于对照组,HDL-C水平高于对照组(P<0.05)。结论 尿毒清颗粒联合他克莫司胶囊治疗肾病综合征能有效改善肾功能,纠正脂质代谢紊乱,提高疗效,且安全性较高。
[Key word]
[Abstract]
Objective To analyze the effect of Niaoduqing Granules combined with Tacrolimus Capsules in treatment of nephrotic syndrome. Methods Patients (94 cases) with nephrotic syndrome in Zhumadian Central Hospital from January 2019 to December 2020 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were po administered with Tacrolimus Capsules, 0.05 mg/kg, once daily, and the blood concentration was maintained at 10 ng/mL. Patients in the treatment group were po administered with Niaoduqing Granules at 6:00, 12:00, and 18:00 on the basis of the control group, 5 g/time, and taken orally 10 g at 22:00 every day. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and renal function (Scr, BUN, and 24 h Upro) and lipid metabolism (TG and HDL-C) in two groups were compared. Results After treatment, the total effective rate of the treatment group was 93.62%, which was higher than 78.72% of the control group (P<0.05). After treatment, the levels of Scr, BUN, and 24 h Upro in two groups were decreased (P<0.05), and the levels of Scr, BUN, and 24 h Upro in the treatment group were lower than those in the control group (P<0.05). After treatment, the levels of TG in two groups were decreased, but the levels of HDL-C in two groups were increased (P<0.05). The levels of TG in the treatment group was lower than that in the control group, but the levels of HDL-C was higher than that in the control group (P<0.05). Conclusion Niaoduqing Granules combined with Tacrolimus Capsules can effectively improve the renal function with nephrotic syndrome, correct the disorder of lipid metabolism, improve the therapeutic effect, with good safety.
[中图分类号]
R983
[基金项目]
河南省科技发展计划项目(152102310008)