目的 优化柴银颗粒的水煎煮工艺。方法 以出膏率、连翘苷转移率为考察指标，以加水量、煎煮次数和煎煮时间为考察因素，在单因素试验基础上运用Box-Behnken响应面法进行优化，确定最佳工艺条件，并进行验证。结果 优化后的工艺为煎煮3次，每次加水11倍量，煎煮1.5 h。结论 Box-Behnken响应面优化的煎煮工艺可用于柴银颗粒的提取。

Objective To optimize the extraction technology of Chaiyin Granules. Methods Taking paste rates and transfer rate of forsythin as index, volume fractions of water, extraction times, and extraction time as factors, based on single factor experiment, Box-Behnken design-response surface method was used to optimize the extraction technology of Chaiyin Granules. The verification tests were carried out on the optimized extraction technology. Results The optimal extraction technology included that 11 times of water, 3 extraction times, and extracting for 1.5 h each time. Conclusion Box-Behnken response surface methodology can be used to optimize the extraction technology of Chaiyin Granules .

R284.2

山东省重点研发计划（重大科技创新工程）项目（2020CXGC010505）