目的 分析解放军总医院第一医学中心门诊抗血栓药物使用情况，分析用药特点，指导合理用药。方法 采用世界卫生组织推荐限定日剂量法，对医院门诊抗血栓药物销售金额、用药频度（DDDs）、日均费用（DDC）以及金额排序与用药频度排序比值（B/A）进行回顾性分析。结果 抗血小板药物销售金额和DDDs排序靠前，抗凝药物居中，溶栓药物使用频率最低。舒洛地特、贝前列素钠、达比加群酯、蚓激酶、替格瑞洛和依诺肝素钠DDDs呈增长趋势，阿司匹林、华法林、前列地尔和双嘧达莫呈下降趋势。DDC值为0.69～10 721.16元，区间大，且多数品种DDC在2017—2018年略有下降，2018—2019年比较稳定。传统药物如阿司匹林、华法林、肝素钠等B/A均≥1.00，其他均<1.00。结论 医院门诊抗血栓药应用情况基本合理，但对个别金额增长较快的药品，需密切关注。

Objective To analyze the use of antithrombotic drugs in The First Medical Center of PLA General Hospital, and analyze the characteristics of drug use, and guide rational drug use. Methods The consumption sum, DDDs, DDC, and B/A of antithrombotic drugs in outpatient department of The First Medical Center of PLA General Hospital from 2017 to 2019 were retrospectively analyzed by using who recommended limited daily dose method. Results The consumption sum and DDDs of antiplatelet drugs ranked first, anticoagulants ranked middle, and the use frequency of thrombolytic drugs was the lowest. The DDDs of sulodexide, beprost sodium, dabigatran, lumbrokinase, ticagrelor, and enoxaparin sodium were increased, while aspirin, warfarin, alprostadil, and dipyridamole were decreased. The DDC value was 0.69 to 10 721.16, and the DDC of most varieties were decreased slightly from 2017 to 2018, but remained stable from 2018 to 2019. B/A of traditional drugs, such as aspirin, warfarin and heparin sodium, were all ≥ 1.00, while others were all < 1.00. Conclusion The application of antithrombotic drugs in outpatients of The First Medical Center of PLA General Hospital is basically reasonable, but attention should be paid to some drugs with rapid increase in amount.

R971