目的 探讨脑安颗粒联合阿司匹林肠溶片治疗急性脑梗死的临床疗效。方法 选取2018年6月—2021年2月河南理工大学第一附属医院收治的68例急性脑梗死患者作为研究对象，根据随机数字表法将68例患者分为对照组和治疗组，每组各包括34例。对照组口服阿司匹林肠溶片，100 mg/次，1次/d。治疗组在对照组基础上口服脑安颗粒，1.2 g/次，2次/d。两组患者连续治疗4周。观察两组的临床疗效，比较两组神经功能、血液流变学和血清因子水平。结果 治疗后，治疗组患者的总有效率为94.12%，对照组的总有效率为76.47%，组间对比差异有统计学意义（P<0.05）。治疗后，两组的美国国立卫生卒中量表（NIHSS）评分显著降低（P<0.05），治疗组NIHSS评分比对照组降低更明显（P<0.05）。治疗后，两组的纤维蛋白原、血小板聚集性、血浆比黏度显著降低（P<0.05）；治疗后，治疗组的纤维蛋白原、血小板聚集性、血浆比黏度低于对照组，差异有统计学意义（P<0.05）。治疗后，两组的正五聚体蛋白-3（PTX-3）、血小板活化因子（PAF）、缺血修饰白蛋白（IMA）水平显著降低（P<0.05）；治疗组的PTX-3、PAF、IMA水平低于对照组，差异有统计学意义（P<0.05）。结论 脑安颗粒联合阿司匹林肠溶片治疗急性脑梗死的疗效确切，可改善血液流变学和神经功能，减轻炎症反应，且安全性良好。

Objective To investigate the clinical efficacy of Naoan Granules combined with Aspirin Enteric-Coated Tablets in treatment of acute cerebral infarction. Methods Patients (68 cases) with acute cerebral infarction in the First Affiliated Hospital of Henan University of Technology from June 2018 to February 2021 were randomly divided into control and treatment groups, and each group had 34 cases. Patients in the control group were po administered with Aspirin Enteric-coated Tablets, 100 mg/time, once daily. Patients in the treatment group were po administered with Naoan Granules on the basis of the control group, 1.2 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and nerve function, hemorheology, and serum factors in two groups were compared. Results After treatment, the total effective rate was 94.12% in the treatment group, and 76.47% in the control group, and there was significant difference between two groups (P < 0.05). After treatment, the NIHSS score of two groups were significantly decreased (P < 0.05), and the NIHSS score of the treatment group were significantly lower than that of the control group (P < 0.05). After treatment, the fibrinogen, platelet aggregation, and plasma specific viscosity in two groups were significantly decreased (P < 0.05). After treatment, the fibrinogen, platelet aggregation, and plasma specific viscosity in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of PTX-3, PAF, and IMA in group were significantly lower than those in the control group (P < 0.05). Conclusion Naoan Granules combined with Aspirin Enteric-Coated Tablets has clinical curative effect in treatment of acute cerebral infarction, can improve hemorheology and nerve function, reduce inflammatory reaction, with good safety.

R971

河南省医学科技攻关计划项目（2018020852）