甲基莲心碱是从睡莲科植物莲Nelumbo nucifera成熟种子的胚芽中提取出的一种双苄基异喹啉类生物碱，具有抗动脉粥样硬化、抗高血压、抗血栓、抗糖尿病血管病变和血管保护作用、抗心律失常等作用。心血管疾病是全球发病率和死亡率最高的一类疾病，包括心绞痛、高血压、高血脂、动脉粥样硬化。近年来，有研究表明甲基莲心碱对心血管疾病防治具有疗效好、副作用低的特点。对甲基莲心碱在心血管疾病中的药理作用及其机制进行综述，为甲基莲心碱的药物研发和临床应用提供参考。

Neferine, a bisbenzyl isoquinoline alkaloid, was extracted from the seed embryo of Nelumbo nucifera Gaertn. It has multiple pharmacological effects, including anti-atherosclerosis, anti-hypertension, anti-thrombosis, anti-diabetic vascular disease and vascular protection, and anti-arrhythmic effect. Cardiovascular diseases are the highest morbidity and mortality in the world, including angina pectoris, hypertension, hyperlipidemia, and atherosclerosis. Recently, more and more studies have shown that neferine has the characteristics of good curative effect and low side effects in the prevention and treatment of cardiovascular diseases. This article reviews the pharmacological effects and mechanisms of neferine in cardiovascular diseases, and provides references for the drug development and clinical application of neferine.

R285;R972

江西省教育厅科学技术研究项目（GJJ180809）；赣南医学院科研课题（YB201801）；心脑血管疾病防治教育重点实验室开放课题（XN202025）