[关键词]
[摘要]
微小RNA(microRNA,简写miRNA)是一类长度为16~22个核苷酸的非编码RNA分子。大量证据表明,miRNA通过影响其生物合成、辐射相关信号转导通路、DNA损伤反应等多个环节有效控制肿瘤细胞辐射敏感性,可用于改善癌症放疗效果,并作为辐射暴露的生物标记物。阐述miRNA的辐射敏感性和其生物标记方面的研究进展,为肿瘤治疗和辐射防护提供思路。
[Key word]
[Abstract]
MicroRNAs (miRNAs) are a class of non-coding RNA molecules consisting of 16 to 22 nucleotides. A large amount of evidence shows miRNAs can effectively control the radiation sensitivity of tumor cells by affecting their biogenesis, radiation-related signal transduction pathways and DNA damage response. It can be used to improve the effectiveness of cancer radiotherapy and as a biomarker for radiation exposure. This paper reviews the research progress on miRNA in radiation sensitivity and its biomarkers, in order to provide new ideas for tumor treatment and radiation protection.
[中图分类号]
R979.6
[基金项目]
国家自然科学基金资助项目(81673106)