[关键词]
[摘要]
目的 分析天津市安定医院住院患者服用抗精神分裂药物所致不良反应(ADR)的情况与特点,为临床合理用药提供参考依据。方法 对2017年1月-2020年12月天津市安定医院主动上报至国家不良反应监测中心的与抗精神分裂症药品相关的88例ADR报告进行分析。结果 产生ADR的患者中31~40岁年龄段占比最高,致ADR药物排名前3的为利培酮、奥氮平、氨磺必利,不良反应时间大于14 d的案例最多,ADR累及多个器官和系统,主要涉及神经精神系统和心脑血管,抗精神分裂药物ADR临床表现多见于患者产生锥体外系反应。结论 目前临床应用的抗精神分裂药物致ADR发生的几率仍然存在,需要加强患者用药期间监测,根据实际情况动态优化用药方案,降低不良反应发生率。
[Key word]
[Abstract]
Objective To analyze the situation and characteristics of adverse reactions (ADR) caused by antischizophrenic drugs in Tianjin Anding Hospital, and to provide reference for rational drug use in clinic. Methods To analyze 88 ADR reports related to antischizophrenia drugs voluntarily reported to National Adverse reaction Monitoring Center by Tianjin Anding Hospital in from January 2017 to December 2020. Results The proportion of ADR patients aged from 31 to 40 was the highest. The top 3 ADR causing drugs were risperidone, olanzapine, and aminosulpiride. The adverse reaction time longer than 14 days was the most common. ADR involves multiple organs and systems, mainly involving the neuropsychiatric system and cardiovascular and cerebrovascular systems. The clinical manifestations of antischizophrenic ADR are more common in patients with extrapyramidal reactions. Conclusion At present, the incidence rate of ADR caused by antischizophrenia drugs still exists in clinical application, so it is necessary to strengthen the monitoring of patients during medication, dynamically optimize medication regimen according to the actual situation, and reduce the incidence of adverse reactions.
[中图分类号]
R971
[基金项目]