目的 探讨美托洛尔联合阿托伐他汀钙治疗冠心病心绞痛的临床效果。方法 选取2019年1月-2020年12月高州市人民医院收治的冠心病心绞痛患者80例为研究对象，所有患者随机分为对照组和治疗组，每组各40例。对照组口服阿托伐他汀钙片，20 mg/次，1次/d，根据个体差异不同适当增加药物剂量，每天总剂量勿超过80 mg。治疗组在对照组基础上口服琥珀酸美托洛尔缓释片，23.75 mg/次，1次/d，每日最大剂量不超过100 mg。两组均持续服用6个月。观察两组的临床疗效，比较两组心绞痛发作情况和血脂水平的变化。结果 治疗后，治疗组总有效率是95.00%，显著高于对照组的77.50%（P<0.05）。治疗后，两组心绞痛持续时间、发作次数均显著降低（P<0.05）；治疗后，治疗组心绞痛发作频率和持续时间显著低于对照组（P<0.05）。治疗后，两组低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、三酰甘油（TG）均较治疗前显著降低（P<0.05）；治疗后治疗组血脂水平低于对照组（P<0.05）。结论 美托洛尔联合阿托伐他汀钙治疗冠心病心绞痛具有较好的临床疗效，可有效控制患者心绞痛发作频率，改善其血脂水平，值得临床推广。

Objective To investigate the clinical effect of metoprolol combined with atorvastatin in treatment of coronary heart disease angina pectoris. Methods A total of 80 patients with coronary heart disease angina pectoris admitted to the People's Hospital of Gaozhou from January 2019 to December 2020 were selected as the study subjects. All patients were randomly divided into control group and treatment group, with 40 cases in each group. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. The drug doesag should be increased appropriately according to individual differences, and the total dosage should not be exceed 80 mg/d. Patients in the treatment group were po administered with Metoprolol Tartrate Sustained-release Tablets on the basis of the control group, 23.75 mg/time, once daily, with a maximum daily dosage not more than 100 mg. Both groups continued to take the drug for 6 months. The clinical efficacy of the two groups was observed and the changes of angina pectoris attack and blood lipid levels were compared between two groups. Results After treatment, the total effective rate of the treatment group was 95.00%, significantly higher than that of the control group (77.50%) (P<0.05). After treatment, the duration and frequency of angina pectoris in both groups were significantly decreased (P<0.05). After treatment, the frequency and duration of angina attack in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) in two groups were significantly decreased compared with before treatment (P<0.05). After treatment, the serum lipid level in the treatment group was lower than that in the control group (P<0.05). Conclusion Metoprolol combined with atorvastatin calcium has good clinical efficacy in the treatment of coronary heart disease angina pectoris, and can effectively control the frequency of angina pectoris attack and improve the level of blood lipid, which is worthy of clinical promotion.

R972