目的 探讨金栀洁龈含漱液联合甲硝唑口颊片治疗牙周炎的临床疗效。方法 选取2018年10月-2020年10月在天津市第五中心医院门诊牙科治疗的118例牙周炎患者，随机分为对照组和治疗组，每组各59例。对照组患者饭后含服甲硝唑口颊片，将药片置于牙龈和龈颊沟间含服，1片/次，3次/d。治疗组患者在对照组的基础上给予金栀洁龈含漱液，15 mL/次，3次/d，含漱1 min即可。两组均连续治疗7 d。观察两组的临床疗效，比较两组临床症状缓解时间、牙周探诊相关指标和血清炎性因子水平。结果 治疗后，治疗组总有效率是98.31%，显著高于对照组83.05%（P<0.05）。治疗后，治疗组患者牙龈出血缓解时间、红肿缓解时间、充血缓解时间、疼痛缓解时间均显著短于对照组（P<0.05）。治疗后，两组患者牙周菌斑指数（PLI）、牙龈沟出血指数（SBI）、牙周袋深度（PD）、牙周附着丧失（AL）指标均显著降低（P<0.05）；治疗后，治疗组牙周相关指标改善优于对照组（P<0.05）。治疗后，两组血清炎性因子白细胞介素6（IL-6）、白细胞介素1β（IL-1β）、C反应蛋白（CRP）水平均显著降低，但白细胞介素10（IL-10）显著升高（P<0.05）；治疗后，治疗组炎性因子水平改善优于对照组（P<0.05）。结论 金栀洁龈含漱液联合甲硝唑口颊片治疗牙周炎效果显著，临床症状好转明显，能有效改善牙周组织状态，并能降低局部炎症反应，值得临床借鉴与推广。

Objective To investigate the clinical curative effect of Jinzhi Jieyin Gargle combined with Metronidazole Buccal Tablets in treatment of periodontitis. Methods A total of 118 patients with periodontitis who received outpatient dental treatment in Tianjin Fifth Central Hospital from October 2018 to October 2020 were randomly divided into control group and treatment group, with 59 cases in each group. Patients in the control group were given Metronidazole Buccal Tablets after meal, which was placed between gingiva and gingival buccal sulcus, 1 tablet/time, 3 times daily. Patients in the treatment group were given Jinzhi Jieyin Gargle for 1 min on the basis of the control group, 15 mL/time, 3 times daily. Both groups were treated for 7 d. The clinical efficacy of the two groups were observed, and the remission time of clinical symptoms, related indexes of periodontal examination and serum inflammatory factors were compared between the two groups. Results After treatment, the total effective rate of treatment group was 98.31%, significantly higher than that of control group 83.05% (P<0.05). After treatment, the remission time of gingival bleeding, redness and swelling, congestion and pain in treatment group was significantly shorter than that in control group (P<0.05). After treatment, periodontal plaque index (PLI), gingival sulcus bleeding index (SBI), periodontal pocket depth (PD), and periodontal attachment loss (AL) in treatment group were significantly decreased (P<0.05). After treatment, the improvement of periodontal related indexes in the treatment group was better than that in the control group (P<0.05). After treatment, the levels of interleukin 6 (IL-6), interleukin 1β (IL-1β) and C-reactive protein (CRP) in serum of two groups were significantly decreased, but interleukin 10 (IL-10) was significantly increased (P<0.05). After treatment, the improvement of inflammatory factors in the treatment group was better than that in the control group (P<0.05). Conclusion Jinzhi Jieyin Gargle combined with Metronidazole Buccal Tablets has significantly effective in treatment of periodontitis, and can effectively improve the status of periodontal tissue and reduce local inflammatory reaction, which is worthy of clinical reference and promotion.

R988.2

天津市科技计划项目（17JCTP254）