[关键词]
[摘要]
目的 观察明目蒺藜丸联合聚乙烯醇滴眼液治疗干眼症的临床疗效。方法 选取2018年12月-2020年12月中国人民解放军联勤保障部队第988医院收治的180例干眼症患者,根据信封抽签法将患者分为对照组和治疗组,各90例。对照组患者给予聚乙烯醇滴眼液,滴于患侧眼部,1滴/次,3~4次/d。治疗组在对照组治疗的基础上口服明目蒺藜丸,9 g/次,2次/d。两组患者持续治疗4周。观察两组疗效,比较两组的视觉相关生命质量量表(NEI-VFQ-25)评分、干眼症症状评分、泪液分泌试验(SIT)、角膜荧光染色(FL)、泪膜破裂时间(BUT)、炎症因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平。结果 治疗后,治疗组的总有效率(94.44%)高于对照组(81.11%)(P<0.05)。治疗后,两组NEI-VFQ-25各维度评分升高(P<0.05),且治疗组NEI-VFQ-25各维度评分高于对照组(P<0.05)。治疗后,两组干眼症症状评分降低(P<0.05),且治疗组干眼症症状评分低于对照组(P<0.05)。治疗后,两组BUT、SIT升高,FL降低,差异有统计学意义(P<0.05);治疗组BUT、SIT高于对照组,FL低于对照组(P<0.05)。治疗后,两组TNF-α、IL-6、hs-CRP水平均显著降低(P<0.05),治疗组TNF-α、IL-6、hs-CRP水平低于对照组(P<0.05)。结论 明目蒺藜丸联合聚乙烯醇滴眼液治疗干眼症的疗效较好,能够提高患者视觉相关生命质量,改善症状,促进泪液分泌,增加泪膜稳定性,减轻角结膜损伤,降低泪液中的炎症因子水平。
[Key word]
[Abstract]
Objective To observe the clinical effect of Mingmu Jili Pills combined with Polyvinyl Alcohol Eye Drops in treatment of dry eye. Methods Patients (180 cases) with dry eye in 988 Hospital of Joint Service Support Force of Chinese People's Liberation Army from December 2018 to December 2020 were divided into control and treatment groups according to the envelope lottery, and each group had 90 cases. Patients in the control group were given Polyvinyl Alcohol Eye Drops, 1 drop/time, 3-4 times daily. Patients in the treatment group were po administered with Mingmu Jili Pills on the basis of the control group, 9 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and NEI-VFQ-25 scores, dry eye symptom scores, SIT, FL, BUT, and inflammatory factor (TNF-α, hs-CRP, and IL-6) in two groups were compared. Results After treatment, the total effective rate of the treatment group (94.44%) was higher than that of the control group (81.11%) (P<0.05). After treatment, the scores of NEI-VFQ-25 in two groups increased (P<0.05), and the scores of NEI-VFQ-25 in the treatment group were higher than those in the control group (P<0.05). After treatment, the symptom score of dry eye in two groups were decreased (P<0.05), and the symptom score of dry eye in the treatment group was lower than that in the control group (P<0.05). After treatment, the BUT and SIT in two groups were increased, but the FL in two groups were decreased (P<0.05). The BUT and SIT in the treatment group were higher than those in the control group, but the FL in the treatment group was lower than those in the control group (P<0.05). After treatment, the levels of TNF-α, IL-6, and hs-CRP in the two groups were significantly decreased (P<0.05), and the levels of TNF-α, IL-6, and hs-CRP in the treatment group were lower than those in the control group (P<0.05). Conclusion Mingmu Jili Pills combined with Polyvinyl Alcohol Eye Drops has clinical curative effect in treatment of dry eye, can improve patients' visual related quality of life, improve symptoms, promote tear secretion, increase tear film stability, reduce keratoconjunctival injury and reduce the level of inflammatory factors in tears.
[中图分类号]
R988.1
[基金项目]
河南省医学科技攻关计划项目(2017T03237)