[关键词]
[摘要]
目的 探讨鹿川活络胶囊联合酮洛芬缓释片治疗膝骨关节炎的临床疗效。方法 回顾性分析2020年2月-2021年2月在天津市宝坻区人民医院治疗的106例膝骨关节炎患者临床资料,根据用药差别分为对照组和治疗组,每组各53例。对照组患者口服酮洛芬缓释片,75 mg/次,2次/d;治疗组患者在对照组基础上口服鹿川活络胶囊,1.35 g/次,3次/d。两组均经4周治疗进行效果比较。观察两组的临床疗效,比较两组治疗前后相关评分、血清学指标、超声指标的变化情况。结果 经治疗,治疗组患者总有效率是98.11%,显著高于对照组的81.13%(P<0.05)。经治疗,两组患者Lysholms评分显著升高,但VAS评分、WOMAC评分、ISOA评分及临床症状评分均显著降低(P<0.05),治疗后,治疗组相关评分改善优于对照组(P<0.05)。经治疗,两组患者髌上囊积液深度、腘窝囊肿范围、滑膜厚度均显著降低,但股骨内外侧髁软骨厚度均显著增加(P<0.05);治疗后,治疗组软骨病变情况及滑膜组织改善优于对照组(P<0.05)。经治疗,两组血清金属蛋白酶组织抑制因子1(TIMP-1)显著升高,但白细胞介素-1β(IL-1β)、血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)、白细胞介素-6(IL-6)均显著降低(P<0.05);且治疗后,治疗组炎症介质水平改善优于对照组(P<0.05)。结论 鹿川活络胶囊联合酮洛芬缓释片治疗膝骨关节炎具有较好的临床疗效,可有效改善患者症状和关节功能,降低炎症介质水平和滑膜组织损伤,有着良好的临床应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Luchuan Huoluo Capsules combined with ketoprofen in treatment of knee osteoarthritis. Methods The clinical data of 106 patients with knee osteoarthritis treated in Tianjin Baodi Hospital from February 2020 to February 2021 were retrospectively analyzed. They were divided into control group and treatment group according to medication difference, with 53 cases in each group. Patients in the control group were po administered with Ketoprofen Sustained Release Tablets, 75 mg/time, twice daily. Patients in the treatment group were po administered with Luchuan Huoluo Capsules on the basis of the control group, 1.35 g/time, three times daily. The two groups were compared after 4 weeks of treatment. The clinical efficacy of the two groups were observed, and the changes of related scores, serological indexes and ultrasonic indexes were compared between the two groups before and after treatment. Results After treatment, the total effective rate of treatment group was 98.11%, significantly higher than that of control group 81.13% (P<0.05). After treatment, Lysholms score was significantly increased in two groups, but VAS score, WOMAC score, ISOA score, and clinical symptom score were significantly decreased (P<0.05). After treatment, correlation score improvement in treatment group was better than that in control group (P<0.05). After treatment, the depth of suprapatellar sac fluid, the range of popliteal cyst and synovial thickness were significantly decreased in two groups, but the thickness of medial and lateral femoral condylar cartilage was significantly increased (P<0.05). After treatment, the improvement of cartilage lesion and synovial tissue in the treatment group was better than that in the control group (P<0.05). After treatment, serum tissue inhibitor of metalloproteinase 1 (TIMP-1) was significantly increased, but interleukin-1β (IL-1β), vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and interleukin-6 (IL-6) were significantly decreased in both groups (P<0.05). After treatment, the level of inflammatory mediators in the treatment group was better than that in the control group (P<0.05). Conclusion Luchuan Huoluo Capsules combined with ketoprofen has good clinical efficacy in treatment of knee osteoarthritis, and can effectively improve the symptoms and joint function of patients, and also can reduce the level of inflammatory mediators and synovial tissue damage, which has good clinical application value.
[中图分类号]
R977
[基金项目]
天津市卫生局科技计划项目(2011KZ05)