目的 探讨金胃泰胶囊联合柳氮磺吡啶治疗慢性溃疡性结肠炎的临床疗效。方法 选取2018年9月-2020年9月在天津医科大学第二医院住院治疗的96例溃疡性结肠炎患者，根据随机数字法分为对照组和治疗组，每组各48例。对照组患者口服柳氮磺吡啶肠溶片，4片/次，3次/d。治疗组患者在对照组的基础上口服金胃泰胶囊，3粒/次，3次/d。两组患者连续治疗2周。观察两组的临床疗效，比较两组临床症状缓解时间和血清炎性因子水平。结果 治疗后，治疗组患者总有效率为97.92%，显著高于对照组的85.42%（P<0.05）。治疗后，治疗组患者腹泻缓解时间、腹痛缓解时间、脓血便缓解时间、充血水肿缓解时间、黏膜溃疡缓解时间均显著短于对照组（P<0.05）。治疗后，两组患者白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、C反应蛋白（CRP）水平均显著降低，白细胞介素2（IL-2）显著升高（P<0.05）；治疗后，治疗组患者血清炎性因子水平改善优于对照组（P<0.05）。结论 金胃泰胶囊联合柳氮磺吡啶治疗溃疡性结肠炎具有显著疗效，可有效缓解患者临床症状，降低炎性反应，值得在临床上借鉴与推广使用。

Objective To investigate the therapeutic effect of Jinweitai Capsules combined with sulfasalazine in treatment of chronic ulcerative colitis. Methods A total of 96 patients with ulcerative colitis hospitalized in the Second Hospital of Tianjin Medical University from September 2018 to September 2020 were selected and divided into control group and treatment group according to random number method, with 48 cases in each group. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 4 tablets/time, three times daily. Patients in the treatment group were po administered with Jinweitai Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in both groups were treated for 2 weeks. The clinical efficacy of the two groups were observed, and the remission time of clinical symptoms and the level of serum inflammatory factors were compared between the two groups. Results After treatment, the total effective rate in treatment group was 97.92%, significantly higher than 85.42% in control group (P<0.05). After treatment, the relief time of diarrhea, abdominal pain, pus, blood and stool, hyperemia and edema and mucosal ulcer in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the levels of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) in two groups were significantly decreased compared with before treatment, but interleukin 2 (IL-2) was significantly increased (P<0.05). After treatment, the improvement of serum inflammatory factors in treatment group was better than that in control group (P<0.05). Conclusion Jinweitai Capsules combined with sulfasalazine has significant curative effect in treatment of chronic ulcerative colitis, and can effectively relieve the clinical symptoms of patients and reduce the inflammatory reaction, which is worthy of clinical reference and promotion.

R975

天津市卫生计生委、天津市中医药管理局中医、中西医结合科研项目（2017095）