目的 探讨桉柠蒎肠溶软胶囊联合噻托溴铵奥达特罗吸入喷雾剂对治疗慢性阻塞性肺疾病（COPD）稳定期患者的肺功能及氧化应激水平的影响。方法 选择2019年2月-2021年2月在南阳市中心医院治疗的136例稳定期COPD患者，根据用药的差别分为对照组和治疗组，每组各68例。对照组吸入噻托溴铵奥达特罗吸入喷雾剂，2喷/次，1次/d；治疗组在对照组的基础上口服桉柠蒎肠溶软胶囊，0.3 g/次，2次/d。两组均经14 d治疗。观察两组患者临床疗效，比较治疗前后两组患者APACHE II评分、CAT评分、SGRQ评分、mMRC评分，血清丙二醛（MDA）、8-羟基脱氧鸟苷（8-OHdG）、脂质过氧化物（LPO）、蛋白C（PC）、总抗氧化能力（TAC）和超氧化物歧化酶（SOD）水平，及肺功能第1秒用力呼气容积（FEV1）、第1秒用力呼气量占用力肺活量比值（FEV1/FVC）和FEV1占预计值百分比（FEV1%）水平。结果 经治疗，治疗组临床有效率明显高于对照组（98.53%vs 82.35%，P<0.05）。经治疗，两组APACHE II评分、CAT评分、SGRQ评分、mMRC评分均明显下降（P<0.05），且治疗组降低更明显（P<0.05）。经治疗，两组血清MDA、8-OHdG、LPO、PC水平均明显下降，而SOD、TAC明显升高（P<0.05），且治疗组改善更明显（P<0.05）。经治疗，两组FEV1、FEV1%和FEV1/FVC均显著升高（P<0.05），且治疗组升高更明显（P<0.05）。结论 桉柠蒎肠溶软胶囊联合噻托溴铵奥达特罗吸入喷雾剂治疗稳定期COPD不仅可以促进患者肺功能改善，还有利于患者机体氧化应激水平的改善，促进呼吸困难情况的改善，提高患者生活质量。

Objective To investigate the effects of Eucalyptol, Limonene and Pinene Enteric Soft Capsules combined with Tiotropium Bromide and Olodaterol Hydrochloride Inhalation Spray on pulmonary function and oxidative stress in patients with chronic obstructive pulmonary disease (COPD) in stable stage. Methods Patients (136 cases) with stable stage of COPD in Nanyang Central Hospital from February 2019 to February 2021 were divided into control and treatment groups based on different treatments, and each group had 68 cases. Patients in the control group were administered with Tiotropium Bromide and Olodaterol Hydrochloride Inhalation Spray, 2 press/time, once daily. Patients in the treatment group were po administered with Eucalyptol on the basis of the control group, Limonene and Pinene Enteric Soft Capsules, 0.3 g/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, the scores of APACHE II, CAT, SGRQ and mMRC, the serum levels of MDA, 8-OHdG, LPO, PC, SOD and TAC, the pulmonary function of FEV1, FEV1% and FEV1/FVC levels in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (98.53% vs 82.35%, P<0.05). After treatment, the scores of APACHE II, CAT, SGRQ and mMRC score were significantly decreased in two groups, especially in the treatment group (P<0.05). After treatment, the serum levels of MDA, 8-OHdG, LPO and PC were significantly decreased, while SOD and TAC were significantly increased in two groups (P<0.05), and the improvement of the treatment group was more obvious (P<0.05). After treatment, FEV1, FEV1% and FEV1/FVC were significantly increased in two groups (P<0.05), especially in the treatment group (P<0.05). Conclusion Eucalyptol, Limonene and Pinene Enteric Soft Capsules combined with Tiotropium Bromide and Olodaterol Hydrochloride Inhalation Spray in treatment of stable stage of COPD can not only improve the lung function of patients, but also improve the level of oxidative stress, and improve dyspnea and improve the quality of life of patients.

R974

国家卫生计生委医药卫生科技发展研究中心项目（W2015PM044）