目的 探讨牛黄清心丸联合依达拉奉注射液治疗急性脑梗死的临床效果。方法 选取2020年3月-2020年8月天津中医药大学第一附属医院收治的100例急性脑梗死患者，随机分为对照组（n=50）和治疗组（n=50）。对照组患者静脉滴注依达拉奉注射液，30 mg加入100 mL生理盐水中充分稀释，0.5 h内滴注完毕，2次/d。治疗组在对照组治疗基础上口服牛黄清心丸，1丸/d。两组患者均连续治疗14 d。观察两组的临床效果，比较两组治疗前后美国国立卫生研究院卒中量表（NHISS）评分、Barthel指数、超敏C反应蛋白（hs-CRP）的变化情况。结果 治疗后，治疗组总有效率是94.00%，显著高于对照组的82.00%（P<0.05）。治疗后，两组患者Barthel指数均可见升高，但NHISS评分、hs-CRP水平均显著降低（P<0.05）；且治疗后，治疗组Barthel指数高于对照组，而NHISS评分、hs-CRP水平低于对照组（P<0.05）。结论 牛黄清心丸联合依达拉奉治疗急性脑梗死具有良好的协同增效作用，能够改善患者神经功能，提高患者日常生活活动能力，具有临床推广应用价值。

Objective To investigate the clinical effect of Niuhuang Qingxin Pills combined with edaravone in treatment of acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction admitted to the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from March 2020 to August 2020 were randomly divided into control group (n =50) and treatment group (n =50). Patients in the control group were iv administered with Edaravone Injection, 30 mg was fully diluted into 100 mL normal saline, and then intravenous infusion was completed within 0.5 h, twice daily. Patients in the treatment group were po administered with Niuhuang Qingxin Pills on the basis of the control group, 1 pill daily. Both groups were treated for 14 d. The clinical effects of the two groups were observed, and the changes of National Institutes of Health Stroke Scale (NHISS) score, Barthel index, and hs-CRP were compared between the two groups before and after treatment. Results After treatment, the total effective rate of treatment group was 94.00%, significantly higher than that of control group 82.00% (P<0.05). After treatment, Barthel index increased in two groups, but NHISS score and hs-CRP level decreased significantly (P<0.05). After treatment, Barthel index in the treatment group was higher than that in the control group, while NHISS score and hs-CRP levels were lower than those in the control group (P<0.05). Conclusion Niuhuang Qingxin Pills combined with edaravone has good synergistic effect in treatment of acute cerebral infarction, and can improve patients' neurological function and patients' ability of daily living activities, which has clinical application value.

R971

天津中医药大学第一附属医院“拓新工程”科研课题（201909）