目的 比较神效散散剂和巴布剂的透皮吸收效果。方法 采用HPLC法测定神效散散剂和巴布剂中血竭素、三七皂苷R₁。使用扩散池装置，以离体小鼠皮肤为屏障进行体外透皮吸收研究，比较神效散巴布剂和散剂中血竭素、三七皂苷R1的累积渗透量、渗透速率。结果 神效散散剂和巴布剂中血竭素、三七皂苷R₁累积渗透量随着时间的增加而增大，且两种成分的累积渗透量：巴布剂>散剂；渗透速率：巴布剂>散剂。结论 与神效散散剂比较，神效散巴布剂具有更强的透皮吸收效果。

Objective To evaluate the transdermal absorption effect of Shenxiao Powder Cataplasm. Methods Dracorhodin and notoginseng saponin R₁ in Shenxiao Powder Cataplasm and Shenxiao Powder were determined. Diffusion cell device was used, and in vitro transdermal absorption was studies with isolated mouse skin as a barrier. The cumulative penetration and penetration rate of dracorhodin and notoginseng saponin R₁ in Shenxiao Powder Cataplasm and Shenxiao Powder were compared. Results The cumulative penetration of the two dosage forms were increased with the increase of time, and the cumulative penetration of the two main components was:cataplasm > powder; Penetration rate:cataplasm > powder. Conclusion Compared with Shenxiao Powder, Shenxiao Powder Cataplasm has stronger transdermal absorption.

R286.02

天津市中医药重点领域科研项目（2017007）；天津市中医药研究院附属医院院内科研基金资助项目（2020004）