氧化苦参碱具有抗肾缺血再灌注损伤、抗内毒素性肾损伤、抗四氯化碳致慢性肾损伤、抗阿霉素肾病、抗输尿管梗阻大鼠肾间质纤维化和抗高糖、高脂诱导的肾脏纤维化的作用。氧化苦参碱肾脏保护作用的作用机制是抗氧化、抗炎、降血糖、调血脂作用，抑制活性氧（ROS）/TLR4、PERK/ATF4/CHOP、JAK2/STATs、TGF-β1/Smads和NF-κB/TNF-α信号通路，减轻肾损伤炎症反应和细胞外基质沉积，阻滞肾损伤和纤维化。

Oxymatrine has antagonisms to kidney ischemia/reperfusion injury, endotoxic renal injury, CCl₄-inguced chronic renal injury, adriamycin nephrosis, renal interstitial fibrosis after ureteral obstruction in rat, and renal fibrosis induced by high glucose and high fat. Its mechanisms of renal protection are antioxidation, anti-inflammation, hypoglycemia, and hypolipemia of oxymatrine, and inhibiting signaling pathways of ROS/TLR4, PERK/ATF4/CHOP, JAK2/STATs, TGF-β1/Smads, and NF-κB/TNF-α, to alleviate renal tissue inflammation and extracellular matrix deposit, and block renal injury and fibrogenesis.

R983