目的 分析天津市滨海新区汉沽中医医院抗菌药物不良反应（ADR）发生的规律及特点，为临床合理用药提供参考。方法 对2006—2020年天津市滨海新区汉沽中医医院上报国家药品不良反应监测中心的105例抗菌药物致ADR报告进行整理，从患者性别、年龄、抗菌药物种类、临床表现、给药途径等方面进行统计分析。结果 105例ADR报告中，女性患者比例略高于男性，患者年龄≤10岁和>60岁年龄段发生率较高，分别占32.38%、24.76%；头孢菌素类抗菌药物发生ADR例数最多，占25.71%，其次为青霉素类，占21.90%；ADR临床表现主要为皮肤及附件损害，占51.91%；静脉滴注为发生ADR的主要给药途径，占95.24%。结论 应加强抗菌药物不良反应监测工作，确保患者用药安全。

Objective To analyze the regularity and characteristics of adverse drug reaction (ADR) of antibiotics in Hangu Hospital of traditional Chinese medicine in Tianjin Binhai New Area, to provide reference for clinical rational drug use. Methods 105 ADR cases caused by antibiotics reported to National Center for adverse drug reaction monitoring by Hangu Hospital of traditional Chinese medicine in Binhai New Area of Tianjin from 2006 to 2020 were analyzed. Statistical analysis was made on gender, age, types of antibiotics, clinical manifestations and route of adminisration. Results In 105 ADR reports, the proportion of female patients was slightly higher than that of male patients. The incidence rate of patients aged ≤ 10 years and > 60 years was higher, accounting for 32.38% and 24.76% respectively. The most ADR cases were caused by cephalosporins accounting for 25.71%. The second was penicillin, accounting for 21.90%, the main clinical manifestation of ADR was skin and accessory damage, accounting for 51.91%, intravenous drip was the main route of administration, accounting for 95.24%. Conclusion The monitoring of adverse drug reactions should be strengthened to ensure the safety of patients.

R969.3