目的 观察肾炎舒片联合吗替麦考酚酯片治疗慢性肾炎的临床疗效。方法 选取2019年2月—2020年9月在驻马店市中心医院就诊的105例慢性肾炎患者，根据患者病历单双号将其分为对照组（53例）和治疗组（52）例。对照组口服吗替麦考酚酯片，1 g/次，2次/d。治疗组在对照组治疗基础上口服肾炎舒片，6片/次，3次/d。两组患者治疗8周。观察两组的临床疗效，比较两组肾功能指标[24 h蛋白尿定量（24 h UPQ）、肾小球滤过率（eGFR）]、炎症指标[白细胞介素-6（IL-6）、超敏C反应蛋白（hs-CRP）]和免疫指标[免疫球蛋白A（IgA）、补体C3]。结果 治疗后，治疗组的总有效率（94.23%）高于对照组（79.25%）（P<0.05）。治疗后，两组患者24 h UPQ水平低于治疗前，eGFR水平高于治疗前（P<0.05），且治疗组24 h UPQ水平低于对照组，eGFR水平高于对照组（P<0.05）。治疗后，两组hs-CRP、IL-6、IgA水平均低于治疗前，补体C3水平高于治疗前（P<0.05），且治疗组hs-CRP、IL-6、IgA水平低于对照组，补体C3水平高于对照组（P<0.05）。结论 肾炎舒片联合吗替麦考酚酯片治疗慢性肾炎患较吗替麦考酚酯单用疗效好，更利于改善患者肾功能，抑制异常免疫反应，降低炎症反应，安全性较好。

Objective To observe the clinical effect of Shenyanshu Tablets combined with Mycophenolate Mofetil Tablets in treatment of chronic nephritis. Methods Patients (105 cases) with chronic nephritis in Zhumadian Central Hospital from February 2019 to September 2020 were divided into the control group (53 cases) and the treatment group (52 cases) according to the patient's medical records. Patients in the control group were po administered with Mycophenolate Mofetil Tablets, 1 g/time, twice daily. Patients in the treatment group were po administered with Shenyanshu Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the renal function indexes (24 h UPQ and eGFR), inflammatory indexes (IL-6 and hs-CRP) and immune indexes (IgA and complement C3) in two groups were compared. Results After treatment, the total effective rate of the treatment group (94.23%) was higher than that of the control group (79.25%) (P < 0.05). After treatment, the level of 24-h UPQ in two groups was lower than that before treatment, but the level of eGFR was higher than that before treatment (P < 0.05). After treatment, the level of 24-h UPQ in the treatment group was lower than that in the control group, but the level of eGFR was higher than that in the control group (P < 0.05). After treatment, the levels of hs-CRP, IL-6, and IgA in two groups were lower than those before treatment, but the level of complement C3 in two groups was higher than that before treatment (P < 0.05). The levels of hs-CRP, IL-6, and IgA in the treatment group were lower than those in the control group, but the level of complement C3 in the treatment group was higher than that in the control group (P < 0.05). Conclusion Shenyanshu Tablets combined with Mycophenolate Mofetil Tablets has better effect than mycophenolate mofetil alone in treatment of chronic nephritis, which is beneficial to improve renal function, inhibit abnormal immune reaction of patients, reduce inflammatory response, with good safety.

R983

河南省科技发展计划项目（152102310284）