[关键词]
[摘要]
目的 观察少腹逐瘀颗粒联合盐酸左氧氟沙星片治疗慢性盆腔炎的临床疗效。方法 选取2018年7月—2020年7月郑州大学第三附属医院收治的107例慢性盆腔炎患者,采用双色球随机分组法把患者分为对照组(53例)和治疗组(54例)。对照组口服盐酸左氧氟沙星片,100 mg/次,2次/d。治疗组在对照组·治疗的基础上口服少腹逐瘀颗粒,1袋/次,3次/d。14 d为1个疗程,两组患者均治疗3个疗程。观察两组临床疗效,比较两组的盆腔内包块直径、输卵管直径、临床症状消失时间、炎症因子。结果 治疗后,治疗组的总有效率(88.89%)高于对照组(73.58%)(P<0.05)。治疗后,治疗组患者盆腔包块、下腹疼痛、盆腔积液、腰骶胀痛消失时间均较对照组短(P<0.05)。治疗后,两组输卵管直径、盆腔内包块直径较治疗前缩小(P<0.05),且治疗组输卵管直径、盆腔内包块直径较对照组缩小(P<0.05)。治疗后,两组血清超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平均较治疗前降低(P<0.05),且治疗组血清hs-CRP、TNF-α、IL-6、IL-1β水平较对照组降低更明显(P<0.05)。结论 少腹逐瘀颗粒联合盐酸左氧氟沙星片治疗慢性盆腔炎的疗效较好,可缩短症状消失时间,缩小盆腔内包块直径和输卵管直径,降低炎症反应。
[Key word]
[Abstract]
Objective To observe the clinical effect of Shaofu Zhuyu Granules combined with Levofloxacin Hydrochloride Tablets in treatment of chronic pelvic inflammation. Methods Patients (107 cases) with chronic pelvic inflammation in the Third Affiliated Hospital of Zhengzhou University from July 2018 to July 2020 were divided into the control group (53 cases) and the treatment group (54 cases) according to the two-color ball random method. Patients in the control group were po administered with Levofloxacin Hydrochloride Tablets, 100 mg/time, twice daily. Patients in the treatment group were po administered with Shaofu Zhuyu Granules on the basis of the control group, 1 bag/time, three times daily. A course of treatment was14 d, and patients in two groups were treated for three courses. After treatment, the clinical efficacies were evaluated, and the pelvic mass diameter, the fallopian tube diameter, the disappearance time of clinical symptoms, and the inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group (88.89%) was higher than that of the control group (73.58%) (P < 0.05). After treatment, the disappearance times of pelvic mass, lower abdominal pain, pelvic effusion, and lumbosacral pain in the treatment group were shorter than that in the control group (P < 0.05). After treatment, the pelvic mass diameter and fallopian tube diameter in two groups were smaller than those before treatment (P < 0.05), and the pelvic mass diameter and fallopian tube diameter in the treatment group were smaller than those in the control group (P < 0.05). After treatment, the serum levels of hs-CRP, TNF-α, IL-6, and IL-1β in two groups were lower than those before treatment (P < 0.05), and the serum levels of hs-CRP, TNF-α, IL-6, and IL-1β in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Shaofu Zhuyu Granules combined with Levofloxacin Hydrochloride Tablets has clinical curative effect in treatment of chronic pelvic inflammation, can shorten the disappearance times of symptoms, reduce the diameter of pelvic mass and fallopian tube, and reduce inflammatory reaction.
[中图分类号]
R984
[基金项目]
河南省医学科技攻关计划项目(201602107)