[关键词]
[摘要]
目的 探讨妇炎康复胶囊联合阿奇霉素片治疗慢性盆腔炎的临床疗效。方法 选取2019年11月—2021年3月在天津市泰达医院就诊的112例慢性盆腔炎患者作为对象,按照随机数字表法将112例患者分为对照组和治疗组,每组各56例。对照组口服阿奇霉素片,0.5 g/次,1次/d。治疗组在对照组基础上口服妇炎康复胶囊,4粒/次,3次/d。两组患者连续治疗4周。观察两组的临床疗效,比较两组患者治疗期间下腹痛、腰骶胀痛、白带异常、盆腔肿块的改善时间。检测患者治疗前后血清白细胞介素-1β(IL-1β)、单核细胞趋化蛋白-1(MCP-1)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平。结果 治疗后,治疗组的总有效率为94.64%,对照组的总有效率为82.14%,两组比较有明显差异(P<0.05)。治疗后,治疗组的下腹痛、腰骶胀痛、白带异常、盆腔肿块消失时间均明显短于对照组(P<0.05)。治疗后,两组IL-1β、MCP-1、GM-CSF水平明显降低(P<0.05);治疗后,治疗组的IL-1β、MCP-1、GM-CSF水平比对照组低(P<0.05)。结论 妇炎康复胶囊联合阿奇霉素片治疗慢性盆腔炎的疗效显著,可改善临床症状,降低炎症反应。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Fuyan Kangfu Capsules combined with Azithromycin Tablets in treatment of chronic pelvic inflammatory disease. Methods Women (112 cases) with chronic pelvic inflammatory disease in Tianjin TEDA Hospital from November 2019 to March 2021 were randomly divided into control and treatment groups, and each group had 56 cases. Women in the control group were po administered with Azithromycin Tablets, 0.5 g/time, once daily. Women in the treatment group were po administered with Fuyan Kangfu Capsules on the basis of the control group, 4 grains/time, three times daily. Women in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the improvement time of lower abdominal pain, lumbosacral swelling pain, abnormal leucorrhea, and pelvic mass were compared between two groups. The levels of serum IL-1β, MCP-1, and GM-CSF were measured before and after treatment. Results After treatment, the total effective rate was 94.64% in the treatment group, and 82.14% in the control group, and there was significant difference between two groups (P < 0.05). After treatment, the disappearance times of lower abdominal pain, lumbosacral swelling pain, abnormal leucorrhea, and pelvic mass in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the levels of IL-1β, MCP-1, and GM-CSF were significantly decreased in two groups (P < 0.05). After treatment, the levels of IL-1β, MCP-1, and GM-CSF in the treatment group were lower than those in the control group (P < 0.05). Conclusion Fuyan Kangfu Capsules combined with Azithromycin Tablets is effective in treatment of chronic pelvic inflammatory disease, which can improve clinical symptoms,, reduce inflammatory reaction.
[中图分类号]
R984
[基金项目]
北京市保健科研课题项目(京13-01号)