伏立康唑是多种深部真菌感染的有效治疗药物，但其药动学复杂、治疗窗窄、个体差异大，且其血药浓度易受CYP2C19基因多态性、性别、年龄、联合用药等多种因素影响，因此为提高疗效、减少不良反应，进行治疗药物浓度监测十分重要。就伏立康唑治疗药物浓度监测的影响因素如个体差异大、CYP2C19基因多态性、药物间相互作用多、年龄因素、其他因素等进行综述，旨在为伏立康唑的临床合理应用提供参考。

Voriconazole is an effective treatment for a variety of deep fungal infections, but its pharmacokinetics are complex, the treatment window is narrow, individual differences are large, and its blood concentration is easily affected by CYP2C19 gene polymorphism, gender, age, combination medication, and other factors influence. In order to improve the curative effect and reduce adverse reactions, the concentration monitoring of therapeutic drugs is very important. This article reviews the influencing factors of voriconazole therapeutic drugs, such as large individual differences, CYP2C19 gene polymorphism, multiple drug interactions, and age factors, aiming to provide reference for the reasonable clinical application of voriconazole.

R978.5

安徽医科大学校科研基金项目（2019xkj069）