多糖是石斛属植物重要的药效成分。石斛多糖药理作用产生机制主要与其抗氧化作用、免疫调节作用、调节肠道菌群功能有关。石斛多糖可以通过直接清除自由基发挥直接抗氧化作用，也可以通过提高机体抗氧化酶活性起到间接抗氧化作用。石斛多糖可以通过与免疫细胞膜上的TLR4等受体结合适度激活TLR4-NF-κB等信号通路，直接发挥免疫调节作用，也可以通过调节肠道菌群间接调节免疫功能。在作用方式上，石斛多糖可以完整地被肠道免疫细胞摄取，也可以经胃酸降解产生可吸收的稳定多糖片段，吸收入血发挥作用；石斛多糖可以通过影响肠道的氧化还原状态以及通过在肠道降解产生单糖来直接影响肠道菌群组成。因此，石斛多糖可以通过多种作用途径、以多种形式发挥丰富多样的药理效应。

Polysaccharide is an important active component of Dendrobium Sw. The mechanisms of pharmacological action of Dendrobium polysaccharides is mainly related to antioxidant effect, immune regulation effect and influence on intestinal flora. Dendrobium polysaccharides can directly scavenge free radicals to play a direct antioxidant effect, but also can play an indirect antioxidant role by improving the antioxidant enzyme activity. Dendrobium polysaccharides can moderately activate TLR4-NF-κB and other signaling pathways by binding with TLR4 and other receptors on immune cell membrane, which can directly play the role of immune regulation, or indirectly regulate immune function by regulating intestinal flora. In the mode of action, Dendrobium polysaccharides can be completely absorbed by intestinal immune cells, and can also be degraded by gastric acid to produce stable absorbable polysaccharide fragments, which can be absorbed into the blood to play a role. Dendrobium polysaccharides can directly affect the composition of intestinal flora by affecting the redox state of intestinal tract and producing monosaccharide in intestinal tract. Therefore, Dendrobium polysaccharides can play a variety of pharmacological effects in a variety of ways and forms.

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2019年度高校优秀青年骨干人才国内访学研修项目（gxgnfx2019026）；2020年全国大学生创新创业训练计划项目（202010376053）；安徽省教育厅自然科学研究重点项目（KJ2016A747）；皖西学院2018年第二学期高层次人才科研启动资助项目（WGKQ201802001）；皖西学院2020年度省级质量工程项目（2020szsfkc0908）；皖西学院2020年度校级质量工程项目（wxxy2020056）