目的 调查分析2018—2020年天津市津南医院解热镇痛抗炎药品的应用情况及趋势，为解热镇痛抗炎药品的科学管理和合理应用提供参考。方法 采用数据回顾性方法，对天津市津南医院解热镇痛抗炎药品的用药总金额、用药总数量及构成比、限定日剂量（DDD）值、用药频度（DDDs）及日均费用（DDC）等数据进行统计与分析。结果 本院共有28种解热镇痛抗炎药，涵盖口服、注射、外用3种剂型。2018—2020年本院口服剂型的解热镇痛抗炎药销售金额呈现先上升后下降趋势，构成比逐年上升趋势，到2020年其构成比达到了82.06%。洛索洛芬钠分散片和草乌甲素片的销售金额及构成比稳居前3位。2018—2019年，除了布洛芬混悬液和氨咖黄敏口服溶液的排名发生变化，其他均未变动。其中阿司匹林肠溶片连续3年稳居首位。2018—2020年，硫辛酸注射液和注射用赖氨匹林的DDC排名始终保持前3位，2020年，注射用精氨酸阿司匹林DDC排名跃居第1位。除个别药品B/A高于1.00，其他均接近1.00。结论 本院解热镇痛抗炎药品的管理比较规范，药物使用大致合理。

Objective To investigate and analyze the application and trend of antipyretic, analgesic and anti-inflammatory drugs in Tianjin Jinnan Hospital from 2018 to 2020, and provide references for the scientific management and rational application of antipyretic, analgesic and anti-inflammatory drugs. Methods The data retrospective method was used to determine the total amount of antipyretic analgesic and anti-inflammatory drugs used in Tianjin Jinnan Hospital, the total number of drugs used and the composition ratio, the DDD value, the frequency of use (DDDs) and the average daily cost (DDC) and other data were analyzed. Results There are 28 antipyretic, analgesic and anti-inflammatory drugs in Tianjin Jinnan Hospital, covering three dosage forms: oral, injection, and topical. From 2018 to 2020, the sales amount of oral dosage forms of antipyretic, analgesic and anti-inflammatory drugs in Tianjin Jinnan Hospital showed an upward trend and then a downward trend. The composition ratio increased year by year. By 2020, its composition ratio reached 82.06%. The sales amount and composition ratio of loxoprofen sodium dispersible tablets and aconitine sodium tablets rank among the top three. During 2018—2019, except for the ranking of ibuprofen suspension and aminokaxamine oral solution, there was no change. Among them, aspirin enteric-coated tablets ranked first for three consecutive years. From 2018 to 2020, the DDC rankings of lipoic acid injection and lysine for injection have always maintained the top three positions. In 2020, the DDC ranking of arginine aspirin for injection will jump to the first place. Except for individual drugs whose B/A is higher than 1.00, the others are close to 1.00. Conclusion The management of antipyretic, analgesic and anti-inflammatory drugs in Tianjin Jinnan Hospital is relatively standardized, and the use of drugs is generally reasonable.

R969.3

国家自然科学基金青年项目（81803524）