目的 探讨银翘解毒颗粒联合阿比多尔片治疗甲型流感的疗效及对炎症介质的影响。方法 选取2019年5月—2020年11月在天津市中医药研究院附属医院治疗的96例甲型流感患者，根据用药的差别分成对照组和治疗组，每组各48例。对照组口服盐酸阿比多尔片，0.2 g/次，3次/d；治疗组在对照组基础上口服银翘解毒颗粒，15 g/次，3次/d。两组患者均治疗7 d后。观察两组患者临床疗效，比较治疗前后两组患者临床症状改善时间，血清C反应蛋白（CRP）、白细胞介素-1β（IL-1β）、单核细胞趋化蛋白-1（MCP-1）、血清淀粉样蛋白A（SAA）、肿瘤坏死因子-α（TNF-α）水平。结果 经治疗，治疗组的总有效率明显高于对照组（97.92% vs 83.33%，P<0.05）。经治疗，治疗组在退热时间、咳嗽消失时间、咽喉疼痛消失时间及病毒转阴时间上均短于对照组（P<0.05）。经治疗，两组血清CRP、IL-1β、MCP-1、SAA、TNF-α水平均显著下降（P<0.05），且治疗组最明显（P<0.05）。结论 银翘解毒颗粒联合阿比多尔片治疗甲型流感可有效改善患者临床症状，降低机体炎症介质水平，具有一定的临床推广应用价值。

Objective To investigate the effect of Yinqiao Jiedu Granules combined with Abidol Tablets in treatment of influenza A and its influence on inflammatory mediators. Methods Patients (96 cases) with influenza A in Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital from May 2019 to November 2020 were divided into control and treatment groups according to the difference of medication, and each group had 48 cases. Patients in the control group were po administered with Arbidol Hydrochloride Tablets, 0.2 g/time, three times daily. Patients in the treatment group were po administered with Yinqiao Jiedu Granules on the basis of the control group, 15 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptom, the serum levels of CRP, IL-1β, MCP-1, SAA, and TNF-α in two groups before and after treatment were compared. Results After treatment, the effective rate of the treatment group was significantly higher than that of the control group (97.92% vs 83.33%, P < 0.05). After treatment, the antipyretic time, cough disappearance time, throat pain disappearance time and virus negative time in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the serum levels of CRP, IL-1β, MCP-1, SAA, and TNF-α were significantly decreased in two groups (P < 0.05), especially in the treatment group (P < 0.05). Conclusion Yinqiao Jiedu Granules combined with Abidol Tablets in the treatment of influenza A can effectively improve the clinical symptoms and reduce the level of inflammatory mediators, which has a certain clinical application value.

R974