目的 探讨金荞麦片联合茶碱缓释片治疗老年慢性支气管炎的疗效及对血清学指标的影响。方法 回顾性分析2020年2月—2020年11月在天津市滨海新区大港医院进行治疗的94例老年慢性支气管炎患者，根据所用药物的区别将所有患者分为对照组和治疗组，每组各47例。对照组口服茶碱缓释片，0.2 g/次，2次/d；治疗组在对照组基础上口服金荞麦片，5片/次，3次/d。两组均治疗2周进行效果比较。观察两组的临床疗效，比较两组临床症状改善时间、炎症介质和肺功能指标。结果 经治疗，治疗组总有效率是97.87%，显著高于对照组的82.98%（P<0.05）。经治疗，治疗组咳嗽、气喘、咳痰症状改善时间均短于对照组（P<0.05）。经治疗，两组血清血清降钙素原（PCT）、巨噬细胞炎症蛋白-1α（MIP-1α）、肿瘤坏死因子-α（TNF-α）、巨噬细胞刺激蛋白（MSP）、白细胞介素-6（IL-6）水平均较治疗前显著下降（P<0.05）；且治疗后治疗组炎症介质水平显著低于对照组（P<0.05）。经治疗，两组第一秒用力呼气容积（FEV1）、第一秒用力呼气量占用力肺活量比值（FEV1/FVC）、FEV1占预计值百分比（FEV1%）均上升（P<0.05），并以治疗组升高更显著（P<0.05）。结论 金荞麦片联合茶碱缓释片治疗老年慢性支气管炎具有较好的临床疗效，不仅可促进患者临床症状改善，还促进患者肺功能及血清炎性因子水平改善，有着良好临床应用价值。

Objective To investigate the effect of Jinqiaomai Tablets combined with Theophylline Sustained-release Tablets in treatment of senile chronic bronchitis and its influence on serological indexes. Methods Retrospective analysis was performed on 94 elderly patients with chronic bronchitis who were treated in Dagang Hospital of Binhai New District, Tianjin from February 2020 to November 2020. All patients were divided into control group and treatment group according to the difference of drugs used, with 47 cases in each group. Patients in the control group were po administered with Theophylline Sustained-release Tablets, 0.2 g/time, twice daily. Patients in the treatment group were po administered with Jinqiaomai Tablets on the basis of the control group, 5 tablets/time, three times daily. The clinical efficacy of the two groups was observed, and the improvement time of clinical symptoms, inflammatory mediators and pulmonary function indexes of the two groups were compared. Results After treatment, the total effective rate of treatment group was 97.87%, which was significantly higher than that of control group (82.98%, P < 0.05). After treatment, the symptom improvement time of cough, asthma, and expectoration in treatment group was shorter than that in control group (P < 0.05). After treatment, the serum levels of PCT, macrophage inflammatory protein-1α (MIP-1α), tumor necrosis factor-α (TNF-α), macrophage stimulating protein (MSP), and interleukin-6 (IL-6) in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the level of inflammatory mediators in treatment group were significantly lower than that in control group (P < 0.05). After treatment, FEV1, FEV1/FVC, and FEV1% were increased in both groups(P < 0.05), and the increase was more significant in the treatment group (P < 0.05). Conclusion Jinqiaomai Tablets combined with Theophylline Sustained-release Tablets has good clinical effect in treatment of senile chronic bronchitis, not only can promote the improvement of patients' clinical symptoms, but also promote the improvement of patients' lung function and serum inflammatory factor level, which has good clinical application value.

R974