[关键词]
[摘要]
目的 探讨枣仁安神胶囊联合阿立哌唑对精神分裂症患者血清神经递质、认知功能、生活质量的影响。方法 选取2019年5月—2020年10月黄石市精神病医院收治的82例精神分裂症患者,根据随机数字表法将82例患者分为对照组和治疗组,每组各41例。对照组口服阿立哌唑片,15 mg/次,2次/d。治疗组在对照组基础上口服枣仁安神胶囊,5粒/次,每日睡前1次。两组均连续治疗2个月。观察两组的临床疗效,比较两组阳性与阴性症状量表(PANSS)评分、蒙特利尔认知评估量表(MoCA)评分、生活质量综合评定量表(GQOLI-74)评分和神经递质的变化情况。结果 治疗后,治疗组总有效率为95.12%显著高于对照组的80.49%(P<0.05)。治疗后,两组阳性症状评分、阴性症状评分、一般精神病理症状和PANSS总分均显著降低(P<0.05);且治疗后治疗组PANSS评分显著低于对照组(P<0.05)。治疗后,两组MoCA评分、GQOLI-74评分均较治疗前显著提高(P<0.05);且治以治疗组升高更明显(P<0.05)。治疗后,两组5-羟吲哚乙酸(5-HIAA)、γ-氨基丁酸(GABA)、神经生长因子(NGF)均较治疗前显著升高(P<0.05);且治疗后治疗组神经递质水平高于对照组(P<0.05)。结论 枣仁安神胶囊联合阿立哌唑治疗精神分裂症具有较好的临床疗效,可调节患者血清神经递质的分泌,进一步改善认知功能和生活质量,具有一定的临床应用价值。
[Key word]
[Abstract]
Objective To investigate the effect of Zaoren Anshen Capsules combined with aripiprazole on serum neurotransmitter, cognitive function and life quality in patients with schizophrenia. Methods A total of 82 patients with schizophrenia admitted to Huangshi Psychiatric Hospital from May 2019 to October 2020 were divided into control group and treatment group according to random number table method, with 41 patients in each group. Patients in the control group were po administered with Aripiprazole Tablets, 15 mg/time, twice daily. Patients in the treatment group were po administered with Zaoren Anshen Capsules on the basis of the control group, 5 grains/time, once daily before going to bed. Both groups were treated continuously for 2 months. The clinical efficacy of the two groups was observed. The scores of Positive and Negative Symptomatic Scale (PANSS), Montreal Cognitive Assessment Scale (MOCA), Comprehensive Quality of Life Scale (GQOLI-74) and the changes of neurotransmitters were compared between the two groups. Results After treatment, the total effective rate of 95.12% in treatment group, which was significantly higher than that of control group (80.49%, P < 0.05). After treatment, the positive symptom score, negative symptom score, general psychopathological symptom score and PANSS total score in both groups were significantly decreased (P < 0.05). After treatment, PANSS scores in treatment group were significantly lower than those in control group (P < 0.05). After treatment, MOCA score and GQOLI-74 score in two groups was significantly increased compared with before treatment (P < 0.05). The increase was more significant in the treatment group (P < 0.05). After treatment, 5-hydroxyindole acetic acid (5-HIAA), γ-aminobutyric acid (GABA) and nerve growth factor (NGF) were significantly increased in both groups compared with before treatment. After treatment, the neurotransmitter level in treatment group was higher than that in control group (P < 0.05). Conclusion Zaoren Anshen Capsules combined with Aripiprazole has a good clinical effect in the treatment of schizophrenia, and can regulate the secretion of serum neurotransmitters, further improve cognitive function and life quality, which has certain clinical application value.
[中图分类号]
R971
[基金项目]