[关键词]
[摘要]
目的 探讨盐酸洛美沙星滴耳液联合阿莫西林颗粒治疗儿童急性中耳炎的疗效及对血清炎症介质水平的影响。方法 回顾性分析2020年2月—2021年2月在天津医科大学总医院进行治疗的104例急性中耳炎患儿的临床资料,根据用药差别分为对照组和治疗组,每组各52例。对照组口服阿莫西林颗粒,每日剂量按体质量20~40 mg/kg,分3次口服;治疗组在对照组治疗基础上给予盐酸洛美沙星滴耳液,3滴/次,2次/d,点耳后进行约10 min耳浴。两组治疗10 d进行效果比较。观察两组的临床疗效,比较两组临床症状改善时间、血清炎症介质水平、miR-203a和miR-155水平。结果 治疗后,治疗组总有效率98.08%,显著高于对照组的82.69%(P<0.05)。经治疗,治疗组耳痛、耳闷、耳鸣、流脓等症状改善时间短于对照组(P<0.05)。经治疗,两组血清C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平均较治疗前显著下降(P<0.05);且治疗后,治疗组炎症介质水平低于对照组(P<0.05)。经治疗,两组血清miR-203a和miR-155水平均显著下降(P<0.05);且治疗后,治疗组miR-203a和miR-155水平低于对照组(P<0.05)。结论 盐酸洛美沙星滴耳液联合阿莫西林颗粒治疗儿童急性中耳炎具有较好的临床疗效,可有效改善患儿临床症状,降低机体炎症介质水平,有着良好的临床应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Lomefloxacin Hydrochloride Ear Drops combined with amoxicillin in treatment of children with acute otitis media and its effect on serum inflammatory mediators. Methods Clinical data of 104 children with acute otitis media who were treated in Tianjin Medical University General Hospital from February 2020 to February 2021 were retrospectively analyzed, and divided into control group and treatment group according to medication difference, with 52 cases in each group. Patients in the control group were po administered with Amoxicillin Granules in three times, 20 — 40 mg/kg. Patients in the treatment group were given Lomefloxacin Hydrochloride Ear Drops on the basis of the control group, 3 drops/time, twice daily, ear bath for about 10 min after ear tip. The effects of the two groups were compared after 10 days of treatment. The clinical efficacy of the two groups was observed, and the clinical symptom improvement time, serum inflammatory mediator level, miR-203a and miR-155 levels were compared between two groups. Results After treatment, the total effective rate of the treatment group was 98.08%, which was significantly higher than that of the control group (82.69%, P < 0.05). After treatment, the improvement time of symptoms such as earache, tightness, tinnitus, and purulent discharge in treatment group was shorter than that in control group (P < 0.05). After treatment, the levels of serum C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the level of inflammatory mediators in treatment group was lower than that in control group (P < 0.05). After treatment, the serum miR-203a and miR-155 levels in both groups were significantly decreased (P < 0.05). After treatment, miR-203a and miR-155 levels in the treatment group were lower than those in the control group (P < 0.05). Conclusion Lomefloxacin Hydrochloride Ear Drops combined with amoxicillin has good clinical effect in treatment of children with acute otitis media, and can effectively improve the clinical symptoms of children, reduce the level of inflammatory mediators in the body, which has good clinical application value.
[中图分类号]
R987
[基金项目]
天津市科技计划项目(17JCPJB46710)