目的 探讨尪痹片联合双醋瑞因治疗膝骨关节炎的临床疗效。方法 选取2018年9月—2020年9月在新乡医学院第一附属医院治疗的106例膝骨关节炎患者，根据随机数字表法分为对照组和治疗组，每组各53例。对照组餐后口服双醋瑞因胶囊，1粒/次，1～2次/d。治疗组在对照组基础上口服尪痹片，4片/次，3次/d。两组患者均治疗2个月。观察两组患者临床疗效，比较治疗前后两组患者临床症状缓解时间、VSA评分、WOMAS评分，血清白细胞介素6（IL-6）、白细胞介素-1β（IL-1β）、肿瘤坏死因子α（TNF-α）和超敏C反应蛋白（hs-CRP）水平，及不良反应情况。结果 治疗后，治疗组临床疗效明显高于对照组（P<0.05）。治疗后，治疗组关节疼痛、关节晨僵、关节肿胀缓解时间均明显早于对照组（P<0.05）。治疗1、4、8周后，两组VAS评分和WOMAS评分均显著降低（P<0.05）；且治疗后治疗组患者VAS评分和WOMAS评分均明显低于对照组（P<0.05）。治疗后，两组患者血清炎性因子IL-6、IL-1β、TNF-α、hs-CRP水平均明显降低（P<0.05），且治疗组明显低于对照组（P<0.05）。治疗组药物不良反应总发生率明显低于对照组（P<0.05）。结论 尪痹片与双醋瑞因联合治疗膝骨关节炎，临床效果显著，能有效减轻关节疼痛及降低炎症反应，促进关节功能的恢复。

Objective To investigate the curative effect of Wangbi Tablets combined with diacerein in treatment of knee osteoarthritis. Methods Patients (106 cases) with knee osteoarthritis in the First Affiliated Hospital of Xinxiang Medical University from September 2018 to September 2020 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Diacerein Capsules, 1 grains/time, 1 — 2 times/daily. Patients in the treatment group were po administered with Wangbi Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the relief time of clinical symptom, VSA scores, WOMAS scores, serum inflammatory factor of IL-6, IL-1β, TNF-α, and hs-CRP levels, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effect of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the relief time of joint pain, morning stiffness and joint swelling in the treatment group was significantly earlier than that in the control group (P < 0.05). After 1, 4, and 8 weeks of treatment, VAS score and WOMAS score were significantly decreased in both groups (P < 0.05). After treatment, the scores of VSA and WOMAS in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-6, IL-1β, TNF-α, and hs-CRP in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). The total incidence of adverse drug reactions in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion The clinical effect of Wangbi Tablets combined with diacerein in treatment of knee osteoarthritis is remarkable, which can effectively relieve joint pain, reduce inflammatory reaction, and promote the recovery of joint function.

R977

河南省卫生健康委员会项目（豫卫科教函[2020]30号）