[关键词]
[摘要]
目的 探讨大柴胡颗粒联合左氧氟沙星片治疗慢性胆囊炎的临床疗效。方法 选取2019年3月—2020年3月商丘市第一人民医院收治的150例慢性胆囊炎患者,按照随机数字表法将150例患者分为对照组和治疗组,每组各75例。对照组口服左氧氟沙星片,0.1 g/次,3次/d。治疗组在对照组基础上温水冲服大柴胡颗粒,8.0 g/次,3次/d。两组患者连续治疗14 d。观察两组的临床疗效,比较两组主观疼痛程度、临床症状改善情况和血清炎症因子水平。结果 治疗后,治疗组的总有效率为96.00%,对照组为85.33%,组间比较差异有统计学意义(P<0.05)。治疗后,两组的视觉模拟评分法(VAS)评分显著降低(P<0.05);治疗后,治疗组VAS评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组的胆红素恢复时间、白细胞计数恢复时间、腹痛消失时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组的前白蛋白(PA)水平显著升高,白细胞介素-8(IL-8)、白细胞介素-15(IL-15)水平显著降低(P<0.05);治疗后治疗组的PA水平高于对照组,IL-8、IL-15水平低于对照组,差异有统计学意义(P<0.05)。结论 大柴胡颗粒联合左氧氟沙星片治疗慢性胆囊炎的疗效确切,能改善临床症状,有效控制炎症反应,安全性良好。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Dachaihu Granules combined with Levofloxacin Tablets in treatment of chronic cholecystitis. Methods Patients (150 cases) with chronic cholecystitis in Shangqiu First People’s Hospital from March 2019 to March 2020 were divided into control and treatment groups according to the method of random number table, and each group had 75 cases. Patients in the control group were po administered with Levofloxacin Tablets, 0.1 g/time, three times daily. Patients in the treatment group were po administered with Dachaihu Granules on the basis of the control group, 8.0 g/time, three times daily. Patients in two groups were treated for 14 weeks. After treatment, the clinical efficacies were evaluated, and subjective pain, improvement of clinical symptoms, and serum inflammatory factor levels in two groups were compared. Results After treatment, the total effective rate was 96.00% in the treatment group and 85.33% in the control group, and the difference was statistically significant (P < 0.05). After treatment, the VAS score of two groups were significantly decreased (P < 0.05), and the VAS score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the bilirubin recovery time, white blood cell count recovery time, and abdominal pain disappearance time of the treatment group were shorter than those of the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of PA in two groups were significantly increased, but the levels of IL-8 and IL-15 in two groups were significantly decreased (P < 0.05). After treatment, the levels of PA in the treatment group was higher than that of the control group, but the levels of IL-8 and IL-15 in the treatment group were lower than those of the control group (P < 0.05). Conclusion Dachaihu Granules combined with Levofloxacin Tablets has clinical curative effect in treatment of chronic cholecystitis, can improve the clinical symptoms, effectively control the inflammatory reaction, with good safety.
[中图分类号]
R975
[基金项目]
河南省医学科技攻关计划项目(LHGJ20200935)