目的 探讨脉络通颗粒联合非洛地平缓释片治疗冠心病变异型心绞痛的临床疗效。方法 选取2020年2月—2021年2月在阜外华中心血管病医院进行治疗的88例冠心病变异型心绞痛患者为研究对象，根据住院先后顺序分为对照组和治疗组，每组各44例。对照组患者口服非洛地平缓释片，5 mg/次，1次/d。治疗组在对照组基础上口服脉络通颗粒，6 g/次，3次/d。两组均治疗4周进行效果比较。观察两组的临床疗效，比较两组治疗前后心功能和血脂水平的变化情况。结果 经治疗，治疗组心绞痛总有效率是97.73%，显著高于对照组81.82%（P<0.05）。经治疗，治疗组心电图疗效总有效率是97.73%，显著高于对照组的84.09%（P<0.05）。经治疗，两组心脏指数（CI）、E峰流速/A峰流速（E/A）、心排血量（CO）均较治疗前显著升高（P<0.05）；且治疗后治疗组心功能指标优于对照组（P<0.05）。经治疗，两组血清三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）水平均显著下降，但高密度脂蛋白（HDL）水平均增高（P<0.05）；治疗后，治疗组血脂水平优于对照组（P<0.05）。结论 脉络通颗粒联合非洛地平缓释片治疗冠心病变异型心绞痛具有较好的临床疗效，可有效改善患者症状，改善患者心功能、血脂水平，有着良好的临床应用价值。

Objective To investigate the effect of Mailuotong Granules combined with felodipine in treatment of coronary heart disease variant angina pectoris. Methods A total of 88 patients with coronary heart disease variant angina pectoris who were treated in Fuwai Huazhong Vascular Disease Hospital from February 2020 to February 2021 were selected as the research subjects. According to the order of hospitalization, they were divided into control group and treatment group, with 44 patients in each group. Patients in the control group were po administered with Felodipine Sustained Release Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Mailuotong Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, the changes of cardiac function and blood lipid levels were compared between the two groups before and after treatment. Results After treatment, the total effective rate of angina pectoris in the treatment group was 97.73%, which was significantly higher than that in the control group (81.82%, P < 0.05). After treatment, the total effective rate of ECG in the treatment group was 97.73%, which was significantly higher than that in the control group (84.09%, P < 0.05). After treatment, cardiac index (CI), peak velocity of E/A (E/A), and cardiac output (CO) in two groups were significantly increased compared with before treatment (P < 0.05). After treatment, the heart function of the treatment group was better than that of the control group (P < 0.05). After treatment, the serum triglyceride (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels in two groups were significantly decreased, but the high density lipoprotein (HDL) levels were increased (P < 0.05). After treatment, the level of blood lipid in the treatment group was better than that in the control group (P < 0.05). Conclusion Mailuotong Granules combined with felodipine has good clinical effect in treatment of coronary heart disease variant angina pectoris, and can effectively improve the symptoms of patients, improve the cardiac function and blood lipid levels, which has a good clinical value.

R972

河南省医学科技攻关计划项目（LHGJ20200096）