目的 分析天津市津南医院近2018－2020年降糖药物使用情况，为促进本院降糖药类药物在临床的合理使用提供参考。方法 采用回顾性分析方法，对 2018年1月—2020年12月本院降糖类药物的销售金额、使用频度（DDDs）、日均费用（DDC）等进行统计并排序、分析。结果 本院2018年1月－2020年12月胰岛素类销售金额及构成比呈先下降后上升趋势，口服降糖类药物销售金额及构成比呈先上升后下降趋势，2020年胰岛素类的构成比达到了69.86%。口服剂型的降糖药α-葡萄糖苷酶抑制剂的销售金额及构成比连续3年高居榜首。阿卡波糖片的销售金额始终居首位，瑞格列奈片2 mg的销售金额排名始终居前3位。除了格列美脲片、盐酸吡格列酮胶囊、盐酸吡格列酮片和2019—2020年的的依帕司他片DDC高于10元，其他均低于10元，患者基本无经济负担。胰岛素各种类的金额排序无明显浮动，其速效、预混和长效胰岛素类似物的销售金额始终居前3位。除了2018年的短效动物胰岛素和长效胰岛素类似物的DDC值大于10元，各类胰岛素的DDC值均小于10元。胰岛素各品种的DDC值无明显浮动，且均小于30元。胰岛素类的B/A比值均接近1.00，说明同步性良好。结论 本院降糖类药物使用基本合理，个别药物如阿卡波糖片的使用量明显超过指南中推荐的一线用药二甲双胍类。

Objective To analyze the use of hypoglycemic drugs in Tianjin Jinnan Hospital in recent three years, to provide references for promoting the rational use of hypoglycemic drugs. Methods Using retrospective analysis method, the sales amount, frequency of use (DDDs) and average daily expenses (DDC) of hypoglycemic drugs used in Tianjin Jinnan Hospital from January 2018 to December 2020 were counted and ranked, analysis. Results From January 2018 to December 2020, the sales amount and composition ratio of insulins in Tianjin Jinnan Hospital declined first and then increased. The sales amount and composition ratio of oral hypoglycemic drugs rose first and then declined. The composition ratio of insulin in 2020 reached 69.86%. The sales amount and composition ratio of oral-dose hypoglycemic drugs α-glucosidase inhibitors topped the list for three consecutive years. The sales amount of acarbose tablets always ranks first, and the sales amount of repaglinide tablets 2 mg always ranks in the top three. Except for glimepiride tablets, pioglitazone hydrochloride capsules, pioglitazone hydrochloride tablets and epalrestat tablets from 2019 to 2020, the DDC is higher than 10 yuan, and the others are less than 10 yuan, and patients basically have no financial burden. There is no obvious fluctuation in the amount of various types of insulin, and the sales amount of its quick-acting, pre-mixed and long-acting insulin analogs always ranks in the top three. Except for the DDC values of short-acting animal insulin and long-acting insulin analogues in 2018 that were greater than 10 yuan, the DDC values of all types of insulin were less than 10 yuan. The DDC valuesof various types of insulin did not fluctuate significantly, and they were all less than 30 yuan. The B/A ratio of insulin is close to 1.00, indicating good synchronization. Conclusion The use of hypoglycemic drugs in Tianjin Jinnan Hospital is basically reasonable. The use of individual drugs, such as acarbose tablets, significantly exceeds the first-line metformin recommended in the guidelines.

R977

国家自然科学基金青年项目（81803524）