目的 探讨桂蒲肾清胶囊联合磷霉素氨丁三醇颗粒治疗下尿路感染的临床疗效。方法 选择2018年7月—2020年7月在天津市北辰医院治疗的108例下尿路感染患者，根据使用药物的差别分成对照组和治疗组，每组各54例。对照组口服磷霉素氨丁三醇颗粒，3 g/次，1次/d。治疗组在对照组基础上口服桂蒲肾清胶囊，4粒/次，3次/d。两组患者均治疗5 d。观察两组患者临床疗效，比较治疗前后两组患者尿细菌培养转阴率和症状消失时间，及血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、单核细胞趋化蛋白-1（MCP-1）、血红素氧合酶1（HO-1）和降钙素原（PCT）水平。结果 治疗后，治疗组总有效率为96.30%，明显高于对照组的83.33%（P<0.05）。治疗后，治疗组患者尿细菌培养转阴率为98.15%，显著高于对照组的81.48%（P<0.05）。与对照组相比，治疗组排尿灼急、腰酸痛、小便涩痛、小腹坠胀症状消失时间明显缩短（P<0.05）。治疗后，两组患者血清hs-CRP、IL-6、MCP-1、HO-1、PCT水平均显著降低（P<0.05），且治疗组降低更显著（P<0.05）。结论 桂蒲肾清胶囊联合磷霉素氨丁三醇颗粒治疗下尿路感染效果显著，同时在改善患者临床不适症状和炎症因子水平方面也有着积极意义。

Objective To investigate the efficacy of Guipu Shenqing Capsules combined with fosfomycin tromethamine in treatment of lower urinary tract infection. Methods Patients (108 cases) with lower urinary tract infection in Tianjin Beichen Hospital from July 2018 to July 2020 were divided into control and treatment groups according to the difference drugs, and each group had 54 cases. Patients in the control group were po administered with Fosfomycin Trometamol Granules, 3 g/time, once daily. Patients in the treatment group po administered with Guipu Shenqing Capsules on the basis of the control group, 4 capsules /time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the negative conversion rate of urine bacterial culture, the symptom disappearance time, and the serum levels of hs-CRP, IL-6, MCP-1, HO-1, and PCT in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was 96.30%, which was significantly higher than 83.33% of the control group (P<0.05). After treatment, the negative conversion rate of urinary bacterial culture in the treatment group was 98.15%, which was significantly higher than 81.48% in the control group (P<0.05). Compared with the control group, the disappearance time of urgent urination, low back pain, astringent urination, and abdominal distension in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the serum levels of hs-CRP, IL-6, MCP-1, HO-1, and PCT in two groups were significantly decreased (P<0.05), especially in the treatment group (P<0.05). Conclusion The effect of Guipu Shenqing Capsule combined with fosfomycin tromethamine in treatment of lower urinary tract infection is significant, and which also has positive significance in improving patients' clinical discomfort symptoms and the level of inflammatory factors.

R983