目的 探讨芪参益气滴丸联合盐酸地尔硫（艹卓）片治疗稳定型心绞痛的临床疗效。方法 选择2020年2月—2020年9月在开封市中心医院治疗96例稳定型心绞痛患者，根据住院序号的奇偶性分成对照组（48例）和治疗组（48例）。对照组口服盐酸地尔硫（艹卓）片，30 mg/次，3次/d；治疗组在对照组基础上饭后口服芪参益气滴丸，0.5 g/次，3次/d。两组患者均经4周治疗。观察两组患者临床疗效，比较治疗前后两组患者心绞痛发作次数和持续时间，血清内皮细胞黏附分子1（VCAM-1）、活性氧自由基（ROS）、可溶性CD40配体（sCD40L）、转化生长因子β1（TGF-β1）、人白三烯B4（LTB4）和心肌营养素1（CT-1）水平，及SAQ、Gensini和GQOLI-74评分。结果 经治疗，对照组和治疗组总有效率分别为83.33%和97.92%，两组比较差异具有统计学意义（P<0.05）。经治疗，两组心绞痛发作次数、每次持续时间均显著减少（P<0.05），且治疗组减少更明显（P<0.05）。治疗后，两组VCAM-1、ROS、sCD40L、LTB4、CT-1水平均明显降低，而TGF-β1明显升高（P<0.05），且治疗组这些指标明显好于对照组（P<0.05）。治疗后，两组患者SAQ和GQOLI-74评分显著升高，而Gensini评分显著降低（P<0.05），且治疗组明显好于对照组（P<0.05）。结论 芪参益气滴丸联合盐酸地尔硫（艹卓）片治疗稳定型心绞痛患者可有效改善患者胸痛症状，提高患者生活质量及改善冠状动脉受损情况，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Qishen Yiqi Pills combined with diltiazem hydrochloride in treatment of stable angina pectoris. Methods Patients (96 cases) with stable angina pectoris in Kaifeng Central Hospital from February 2020 to September 2020 were divided into control (48 cases) and treatment (48 cases) groups according to the parity of the hospitalization number. Patients in the control group were po administered with Diltiazem Hydrochloride Tablets, 30 mg/time, three times daily. Patients in the treatment group were po administered with Qishen Yiqi Pills on the basis of the control group, 0.5 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the frequency and duration of angina pectoris, and the serum levels of VCAM-1, ROS, sCD40L, LTB4, CT-1, and TGF-β1, and the scores of SAQ, Gensini, and GQOLI-74 in two groups before and after treatment were compared. Results After treatment, the clinical effective rates of the control group and the treatment group were 83.33% and 97.92%, respectively, and the difference between the two groups was statistically significant (P<0.05). After treatment, the attack times and duration of angina pectoris were significantly decreased in two groups (P<0.05), especially in the treatment group (P<0.05). After treatment, the serum levels of VCAM-1, ROS, sCD40L, LTB4, and CT-1 in two groups were significantly decreased, while TGF- β1 were significantly increased (P<0.05), and these indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the SAQ and GQOLI-74 scores of the two groups were significantly increased, while the Gensini scores were significantly decreased (P<0.05), and the treatment group was significantly better than the control group (P<0.05). Conclusion Qishen Yiqi Pills combined with diltiazem hydrochloride in treatment of stable angina pectoris can effectively improve the symptoms of chest pain, improve the quality of life and improve the damage of coronary artery, which has a certain clinical application value.

R972